CD150/SLAM Recombinant Rabbit mAb (一抗) - WB,Flow-Cyt,IP | Bioss
Rrmab?兔单抗
货号：bsm-62229R
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概述
产品编号
bsm-62229R
产品类型
重组兔单抗
英文名称
CD150/SLAM Recombinant Rabbit mAb
中文名称
信号淋巴细胞活化分子CD150重组兔单抗
英文别名
CD150; CDw150; IPO3; SLAM; 4933415F16; ESTM51; IPO-3; RGD1560634; SLAF1_HUMAN; SLAMF1; SLAM family member 1; SLAF1_MOUSE;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human SLAMF1: 250-300/335
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
6D11
理论分子量
37 kDa
检测分子量
75 kDa
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究领域
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
CD150（SLAM）为70kD的表面糖蛋白属于免疫球蛋白基因超家族。SLAM有直接诱导CD4阳性T细胞克隆与活化前T细胞的作用。CD150抗原还可以增强抗原特异性增生与通过T细胞携带的CD4抗原产生细胞因子，特别是对干扰素-γ具有极强的上调节作用。SLAM与自身配体具有极高亲和性，由SLAM同源亲和细胞间的相互作用能够刺激T淋巴细胞产生自身因子。CD150抗原还是风疹病毒细胞受体并且通过白介素10下调节。
背景资料
High-affinity self-ligand important in bidirectional T-cell to B-cell stimulation. SLAM-induced signal-transduction events in T-lymphocytes are different from those in B-cells.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | 1:500-2000 | |
| Flow-Cyt | Human | 1ug/Test | |
| IP | Human | 1:20-50 |
交叉反应
交叉反应: Human
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靶标
基因名
SLAMF1
蛋白名
Signaling lymphocytic activation molecule
亚基
nteracts (via cytoplasmic domain) with SH2D1A, and withPTPN11. Interacts with INPP5D/SHIP1. Binds to Measles virus Hprotein and acts as a receptor for this virus.
亚细胞定位
Cell membrane; Single-pass type I membrane protein. Note=Present on the surface of B-cells and T-cells.
组织特异性
Constitutively expressed on peripheral blood memory T-cells, T-cell clones, immature thymocytes and a proportion of B-cells, and is rapidly induced on naive T-cells after activation.
翻译后修饰
Phosphorylated by FYN.
相似性
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.
功能
High-affinity self-ligand important in bidirectional T-cell to B-cell stimulation. SLAM-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAM signaling are likely to exist: one in which the inhibitor SH2D1A acts as a negative regulator and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates.
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