生肌决定因子Myf5重组兔单抗

bsm-62224R

重组兔单抗

MYF5 Recombinant Rabbit mAb

生肌决定因子Myf5重组兔单抗

EORVA; bHLHc2; B130010J22Rik; Myf-5; MYF5_HUMAN; MYF5; Class C basic helix-loop-helix protein 2 (bHLHc2); MYF5_MOUSE;

Rabbit

A synthesized peptide derived from human MYF5: 201-255/255

IgG

Liquid

affinity purified by Protein A

Recombinant

4G8

28

37

10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

yf5是MyoD基因家族的一员，该家族的共同结构特点是具有1个保守的中央蛋白基序(motif)，大小为80个氨基酸，称为碱性螺旋-环-螺旋(bHLH)，bHLH高度保守，其中Basic结构是HLH螺旋结构的延伸，也是这一家族蛋白与DNA相互作用的区域，而HLH螺旋结构则是与其他因子相互作用的位点，即调控的重要区域。
生肌决定因子(MyoD)基因家族控制着肌细胞的增殖和分化，与肌纤维的数量、大小有着密切的关系，因而对肉质和风味有非常重要的作用，MyoD基因家族可编码4种不同的转录因子，分别为MyoD(Myf3)、Myogenin(MyoG)、Myf5、Myf6或MRF4，它们各自或协同控制着骨骼肌生成方面的关键调节因子。

Transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYOG and MYOD1, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein.