CHRM2 Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF,IP | Bioss

bsm-62216R

重组兔单抗

CHRM2 Recombinant Rabbit mAb

毒蕈碱型乙酰胆碱受体重组兔单抗

HM2; AChR-M2; Chrm-2; M2; ACM2_HUMAN; CHRM2; cholinergic receptor muscarinic 2; acetylcholine receptor, muscarinic 2

Rabbit

A synthesized peptide derived from human CHRM2: 152-180/466

IgG

Liquid

affinity purified by Protein A

Recombinant

12G9

52 kDa

52 kDa

10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

ChRM2 ( muscarinic acetylcholine receptor M2 ) 毒蕈碱型乙酰胆碱受体通过与G蛋白偶联，调节各种细胞应答，包括抑制腺苷酸环化酶，降解磷酸肌醇和调节钾通道。
毒蕈碱型乙酰胆碱受体（又称：Cholinergic receptor,mucarinic 2）是一类可以被毒蕈碱激活而受阿托品抑制的受体.此抗体真对Cholinergic receptor,mucarinic 2蛋白的N-端部分。

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.

CHRM2

Muscarinic acetylcholine receptor M2

Interacts with ARRB1 and ARRB2. Interacts with GNB2L1/RACK1; the interaction regulates CHRM2 internalization.

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.

Genetic variations in CHRM2 can influence susceptibility to major depressive disorder (MDD) [MIM:608516]. MDD is one of the most common psychiatric disorders. MDD is a complex trait characterized by one or more major depressive episodes without a history of manic, mixed, or hypomanic episodes. A major depressive episode is characterized by at least 2 weeks during which there is a new onset or clear worsening of either depressed mood or loss of interest or pleasure in nearly all activities. Four additional symptoms must also be present including changes in appetite, weight, sleep, and psychomotor activity; decreased energy; feelings of worthlessness or guilt; difficulty thinking, concentrating, or making decisions; or recurrent thoughts of death or suicidal ideation, plans, or attempts. The episode must be accompanied by distress or impairment in social, occupational, or other important areas of functioning.

Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM2 sub-subfamily.

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition.