ZNF348/Kaiso Recombinant Rabbit mAb (一抗) - WB | Bioss
Rrmab?兔单抗
货号：bsm-62183R
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概述
产品编号
bsm-62183R
产品类型
重组兔单抗
英文名称
ZNF348/Kaiso Recombinant Rabbit mAb
中文名称
锌指蛋白348重组兔单抗
英文别名
ZNF-kaiso; ZNF348; E130014G12Rik; Kaiso; RGD1566309; KAISO_HUMAN; ZBTB33; Zinc finger and BTB domain-containing protein 33; KAISO_MOUSE;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human KAISO: 620-672
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
7B3
理论分子量
74 kDa
检测分子量
75 kDa
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究领域
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human, Rat | Mouse | 1:500-2000 |
交叉反应
交叉反应: Human, Rat (predicted: Mouse)
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靶标
基因名
ZBTB33
蛋白名
Transcriptional regulator Kaiso
亚基
Self-associates. Interacts with CTNND2 (By similarity). Interacts with CTNND1, and this interaction inhibits binding to both methylated and non-methylated DNA. Interacts with NCOR1. Interacts with KPNA2/RCH1, which may mediate nuclear import of this protein.
亚细胞定位
Nucleus. Cytoplasm. Also cytoplasmic in cells grown at high densities.
组织特异性
Expressed in vascular endothelium.
相似性
Contains 1 BTB (POZ) domain.
Contains 3 C2H2-type zinc fingers.
Contains 3 C2H2-type zinc fingers.
功能
Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3'. Recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. May contribute to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2.
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