Plasma membrane-anchored serine protease that cleaves at arginine residues.Participates in proteolytic cascades of relevance for the normal physiologic function of the prostate.(Microbial infection) Facilitates human coronaviruses SARS-CoV and SARS-CoV-2 infections via two independent mechanisms, proteolytic cleavage of ACE2 receptor which promotes viral uptake, and cleavage of coronavirus spike glycoproteins which activates the glycoprotein for host cell entry.
产品应用
应用
已检合格种属
预测种属
推荐稀释比例
WB
Human, Mouse
1:500-2000
IHC-P
Human
Mouse
1:100-500
IHC-F
Human
Mouse
1:100-500
IF
Human
Mouse
1:100-500
交叉反应
交叉反应: Human, Mouse
相关产品
暂无相关产品
靶标
基因名
TMPRSS2
蛋白名
Transmembrane protease serine 2
亚细胞定位
Cell membrane and Secreted. Activated by cleavage and secreted.
组织特异性
Expressed strongly in small intestine. Also expressed in prostate, colon, stomach and salivary gland.
相似性
Belongs to the peptidase S1 family. Contains 1 LDL-receptor class A domain. Contains 1 peptidase S1 domain. Contains 1 SRCR domain.
功能
Expressed strongly in small intestine. Also expressed in prostate, colon, stomach and salivary gland.