Involved in the control of reactive oxygen species levels and the regulation of mitochondrial redox homeostasis.Maintains thioredoxin in a reduced state. May play a role in redox-regulated cell signaling.
基因名
TXNRD2
蛋白名
Thioredoxin reductase 2, mitochondrial
亚基
Homodimer.
亚细胞定位
Mitochondrion.
组织特异性
Highly expressed in the prostate, ovary, liver, testis, uterus, colon and small intestine. Intermediate levels in brain, skeletal muscle, heart and spleen. Low levels in placenta, pancreas, thymus and peripheral blood leukocytes. According to PubMed:10608886, high levels in kidney, whereas according to PubMed:9923614, levels are low.
相似性
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
功能
Maintains thioredoxin in a reduced state. Implicated in the defenses against oxidative stress. May play a role in redox-regulated cell signaling.