Pokemon/ZBTB7A Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF,Flow-Cyt,ICC/IF,IP | Bioss

bsm-62165R

重组兔单抗、mIHC精品抗体

Pokemon/ZBTB7A Recombinant Rabbit mAb

扑克蒙蛋白重组兔单抗

FBI-1; FBI1; LRF; MNDLFH; TIP21; ZBTB7; ZNF857A; pokemon; 9030619K07Rik; 9130006G12Rik; ZBT7A_HUMAN; ZBTB7A; Factor binding IST protein 1 (FBI-1); Factor that binds to inducer of short transcripts protein 1; HIV-1 1st-binding protein 1; Leukemia/lymphoma-related factor; POZ and Krueppel erythroid myeloid ontogenic factor (POK erythroid myeloid ontogenic factor | Pokemon | Pokemon 1); TTF-I-interacting peptide 21 (TIP21); Zinc finger protein 857A; ZBT7A_MOUSE; POZ and Krueppel erythroid myeloid ontogenic factor (POK erythroid myeloid ontogenic factor | Pokemon); zinc finger and BTB domain containing 7A; zinc finger and BTB domain containing 7; zinc finger and BTB domain containing 7A, HIV-1 inducer of short transcripts binding protein; lymphoma related factor; POK erythroid myeloid ontogenic factor; leukemia/lymphoma related factor

Rabbit

A synthesized peptide derived from human ZBTB7A: 520-584

IgG

Liquid

affinity purified by Protein A

Recombinant

2B1

61 kDa

73 kDa

10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Pokemon(7APOK Erythroid Myeloid Ontogenic factor)能够控制将正常细胞变成癌细胞所需的途径,Pokemon蛋白是转录因子蛋白家族的一员，并且在人类癌症中发生了突变。另外Pokemon蛋白作为转录因子参与一些细胞基因转录的调节,并在细胞分化过程中发挥着关键、多效性的功能。近来发现,Poke-mon在致癌转化过程中发挥着至关重要的功能,并与肿瘤的发生密切相关。
这种蛋白很可能在实质肿瘤中处于重要地位,还有学者认为：Pokemon在一定类型的B细胞和T细胞淋巴瘤中水平非常高，并发现具有高水平Pokemon蛋白表达对肿瘤恶性程度改变更大。
主要定位于细胞核。
扑克蒙”蛋白又称“波克曼”蛋白。

Transcription factor that represses the transcription of a wide range of genes involved in cell proliferation and differentiation.

ZBTB7A

Zinc finger and BTB domain-containing protein 7A

Interacts with BCL6.

Nucleus.

Widely expressed. In normal thymus, expressed in medullary epithelial cells and Hassle's corpuscles (at protein level). In tonsil, expressed in squamous epithelium and germinal center lymphocytes (at protein level). Up-regulated in a subset of lymphomas, as well as in a subset of breast, lung, colon, prostate and bladder carcinomas (at protein level).

Contains 1 BTB (POZ) domain.
Contains 4 C2H2-type zinc fingers.

Plays a key role in the instruction of early lymphoid progenitors to develop into B lineage by repressing T-cell instructive Notch signals (By similarity). Specifically represses the transcription of the CDKN2A gene. Efficiently abrogates E2F1-dependent CDKN2A transactivation/de-repression. Binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3'.