异柠檬酸脱氢酶1重组兔单抗
Rrmab®兔单抗
货号：bsm-62156R
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概述
产品编号
bsm-62156R
产品类型
重组兔单抗、mIHC精品抗体
英文名称
IDH1 Recombinant Rabbit mAb
中文名称
异柠檬酸脱氢酶1重组兔单抗
英文别名
HEL-216; HEL-S-26; IDCD; IDH; IDP; IDPC; PICD; IDHC_HUMAN; IDH1; Cytosolic NADP-isocitrate dehydrogenase; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase; 1.1.1.42;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human IDH1: 1-70/414
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
20C14
理论分子量
47
检测分子量
45
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究领域
Cancer > Cancer Metabolism > Metabolic signaling pathway > Metabolism of lipids and lipoproteins
Metabolism > Pathways and Processes > Metabolic signaling pathways > Energy transfer pathways > Energy Metabolism
Metabolism > Pathways and Processes > Metabolic signaling pathways > Lipid and lipoprotein metabolism > Lipid metabolism
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍
IDH1又称PICD和IDP，属于异柠檬酸脱氢酶和异丙基苹果酸脱氢酶家族。这是人类原发性脑癌主要亚型的共同特征。基因变异与软骨肿瘤如内生软骨瘤或软骨肉瘤有关。Arg-132到Cys、Gly或His的突变消除了异柠檬酸到α-酮戊二酸的转化。相反，α-酮戊二酸转化为R（-）-2-羟基戊二酸。
背景资料
Catalyzes the NADP+-dependent oxidative decarboxylation of isocitrate (D-threo-isocitrate) to 2-ketoglutarate (2-oxoglutarate), which is required by other enzymes such as the phytanoyl-CoA dioxygenase. Plays a critical role in the generation of NADPH, an important cofactor in many biosynthesis pathways.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human, Mouse, Rat | 1:1000-2000 | |
| IHC-P | Human, Mouse, Rat | 1:200-800 | |
| IHC-F | Human, Mouse, Rat | 1:200-800 | |
| IF | Human, Mouse, Rat | 1:200-800 | |
| IP | Human, Mouse, Rat | 1:20-100 |
交叉反应
交叉反应: Human, Mouse, Rat
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靶标
基因名
IDH1
蛋白名
Isocitrate dehydrogenase [NADP] cytoplasmic
亚基
Homodimer.
亚细胞定位
Cytoplasm. Peroxisome.
疾病
Defects in IDH1 are involved in the development of glioma (GLM) [MIM:137800]. Gliomas are central nervous system neoplasms derived from glial cells and comprise astrocytomas, glioblastoma multiforme, oligodendrogliomas, and ependymomas. Note=Mutations affecting Arg-132 are tissue-specific, and suggest that this residue plays a unique role in the development of high-grade gliomas. Mutations of Arg-132 to Cys, His, Leu or Ser abolish magnesium binding and abolish the conversion of isocitrate to alpha-ketoglutarate. Instead, alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate. Elevated levels of R(-)-2-hydroxyglutarate are correlated with an elevated risk of malignant brain tumors.
相似性
Belongs to the isocitrate and isopropylmalate dehydrogenases family.
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