Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Considered to have intrinsic transcriptional activity, have some natural ligands such as all-trans retinoic acid (ATRA) and other retinoids which act as inverse agonists repressing the transcriptional activity.
产品应用
应用
已检合格种属
预测种属
推荐稀释比例
WB
Human
Mouse
1:1000-2000
Flow-Cyt
Human
Mouse
1:50-100
交叉反应
交叉反应: Human, Mouse
相关产品
暂无相关产品
靶标
基因名
RORB
蛋白名
Nuclear receptor ROR-beta
亚细胞定位
Nucleus (Probable).
相似性
Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain.
功能
Orphan nuclear receptor required for normal postnatal development of rod and cone photoreceptor cells. Regulates transcription of OPN1SW in cone photoreceptor cells by binding the sequence 5'-AGGTCA-3' in the OPN1SW promoter (By similarity).