SMC4 Recombinant Rabbit mAb (一抗) - WB,Flow-Cyt,ICC/IF | Bioss
Rrmab?兔单抗
货号：bsm-62104R
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概述
产品编号
bsm-62104R
产品类型
重组兔单抗
英文名称
SMC4 Recombinant Rabbit mAb
中文名称
染色体结构维持蛋白4重组兔单抗
英文别名
SMC4_HUMAN; SMC4; SMC protein 4; SMC-4; Chromosome-associated polypeptide C (hCAP-C); XCAP-C homolog; CAPC; SMC4L1; CAP-C;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human SMC4: 1200-1250
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
6C1
理论分子量
147 kDa
检测分子量
175 kDa
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究领域
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
背景资料
Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human, Mouse | 1:500-2000 | |
| Flow-Cyt | Human, Mouse | 1:50-100 | |
| ICC/IF | Human, Mouse | 1:50-200 |
交叉反应
交叉反应: Human, Mouse
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靶标
基因名
SMC4
蛋白名
Structural maintenance of chromosomes protein 4
亚基
Forms a heterodimer with SMC2. Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: BRRN1/CAPH, CNAP1/CAPD2 and CAPG.
亚细胞定位
Nucleus. Cytoplasm. Chromosome. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDC2, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.
组织特异性
Widely expressed. Higher expression in testis, colon, thymus.
相似性
Belongs to the SMC family. SMC4 subfamily.
功能
Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
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