丝氨酸/苏氨酸蛋白激酶Nek7重组兔单抗
Rrmab®兔单抗
货号：bsm-62095R
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概述
产品编号
bsm-62095R
产品类型
重组兔单抗
英文名称
NEK7 Recombinant Rabbit mAb
中文名称
丝氨酸/苏氨酸蛋白激酶Nek7重组兔单抗
英文别名
NEK7_HUMAN; NEK7; Never in mitosis A-related kinase 7 (NimA-related protein kinase 7); 2.7.11.34;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human NEK7: 241-302/302
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
4A3
理论分子量
35
检测分子量
35
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究领域
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
背景资料
Protein kinase which plays an important role in mitotic cell cycle progression.Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human, Mouse, Rat | 1:500-2000 | |
| Flow-Cyt | Human, Mouse, Rat | 1:50-100 |
交叉反应
交叉反应: Human, Mouse, Rat
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靶标
基因名
NEK7
蛋白名
Serine/threonine-protein kinase Nek7
亚基
Monomer. Interacts with NEK9.
亚细胞定位
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, centrosome. Note=Present at centrosome throughout the cell cycle. Also detected at spindle midzone of the anaphase cells and eventually concentrates at the midbody.
组织特异性
Highly expressed in lung, muscle, testis, brain, heart, liver, leukocyte and spleen. Lower expression in ovary, prostate and kidney. No expression seen in small intestine.
翻译后修饰
Phosphorylation at Ser-195 required for its activation.
相似性
Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.
Contains 1 protein kinase domain.
Contains 1 protein kinase domain.
功能
Protein kinase which plays an important role in mitotic cell cycle progression. Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis. Phosphorylates RPS6KB1.
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