γ氨基丁酸转氨酶重组兔单抗
Rrmab®兔单抗
货号：bsm-62069R
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概述
产品编号
bsm-62069R
产品类型
重组兔单抗、mIHC精品抗体
英文名称
ABAT Recombinant Rabbit mAb
中文名称
γ氨基丁酸转氨酶重组兔单抗
英文别名
GABA-AT; GABAT; NPD009; 9630038C02Rik; Gabaat; Gm9851; I54; Laibat; beta-AlaAT; GABT_HUMAN; ABAT; (S)-3-amino-2-methylpropionate transaminase; GABA aminotransferase (GABA-AT); Gamma-amino-N-butyrate transaminase (GABA transaminase | GABA-T); L-AIBAT; 2.6.1.19; GABT_MOUSE; GABT_RAT; beta-AlaAT I;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human ABAT: 20-80/500
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
3G10
理论分子量
56
检测分子量
50
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究领域
Cancer > Cancer Metabolism > Response to hypoxia
Metabolism > Pathways and Processes > Metabolic signaling pathways > Amino acid metabolism
Metabolism > Pathways and Processes > Metabolism processes > Hypoxia
Metabolism > Pathways and Processes > Mitochondrial Metabolism > Mitochondrial markers
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Mouse, Rat | Human | 1:500-2000 |
| IHC-P | Human, Mouse, Rat | 1:100-500 | |
| IHC-F | Human, Mouse, Rat | 1:100-500 | |
| IF | Human, Mouse, Rat | 1:100-500 | |
| IP | Human, Mouse, Rat | 1:20-50 |
交叉反应
交叉反应: Human, Mouse, Rat
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靶标
基因名
ABAT
蛋白名
4-aminobutyrate aminotransferase, mitochondrial
亚基
Homodimer; disulfide-linked.
亚细胞定位
Mitochondrion matrix.
组织特异性
Liver > pancreas > brain > kidney > heart > placenta.
疾病
Defects in ABAT are a cause of gamma-aminobutyrate transaminase deficiency (GABA-AT deficiency) [MIM:613163]. The phenotype of this deficiency includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities.
相似性
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
功能
Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine.
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