Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis.
基因名
PCYT1A
蛋白名
Choline-phosphate cytidylyltransferase A
亚基
Homodimer.
亚细胞定位
Cytoplasm; cytosol. Membrane. It can interconvert between an inactive cytosolic form and an active membrane-bound form.
翻译后修饰
The serine residues of the C-terminus are phosphorylated. The inactive soluble form is stabilized by phosphorylation, the active membrane bound form is promoted by anionic lipids or diacylglycerol, and is stabilized by dephosphorylation.