果糖1，6-二磷酸酯酶重组兔单抗
Rrmab®兔单抗
货号：bsm-62000R
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概述
产品编号
bsm-62000R
产品类型
重组兔单抗
英文名称
FBP1 Recombinant Rabbit mAb
中文名称
果糖1，6-二磷酸酯酶重组兔单抗
英文别名
FBP; Fbp-2; Fbp2; Fbp3; Fdp; F16P1_HUMAN; FBP1; FBPase 1; D-fructose-1,6-bisphosphate 1-phosphohydrolase 1; Liver FBPase; 3.1.3.11; F16P1_MOUSE; Fructose-1,6-bisphosphatase isozyme 3 (FBPase 3); F16P1_RAT;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human FBPase 1: 55-87
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
5E8
理论分子量
37
检测分子量
37
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究领域
Cancer > Cancer Metabolism > Metabolic signaling pathway > Metabolism of carbohydrates
Epigenetics and Nuclear Signaling > DNA / RNA > DNA Damage & Repair > DNA Damage Response
Metabolism > Pathways and Processes > Metabolic signaling pathways > Carbohydrate metabolism
Metabolism > Pathways and Processes > Metabolic signaling pathways > Energy transfer pathways > Energy Metabolism
Metabolism > Pathways and Processes > Metabolic signaling pathways > Nucleotide metabolism
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
果糖1，6-二磷酸酯酶又称生长抑制蛋白17，是糖代谢过程中的关键酶，是一个典型的别构酶。
背景资料
Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Mouse | Human, Rat | 1:500-2000 |
| IHC-P | Human, Mouse, Rat | 1:100-500 | |
| IHC-F | Human, Mouse, Rat | 1:100-500 | |
| IF | Human, Mouse, Rat | 1:100-500 |
交叉反应
交叉反应: Human, Mouse, Rat
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靶标
基因名
FBP1
蛋白名
Fructose-1, 6-bisphosphatase 1
亚基
Homotetramer
亚细胞定位
Cytosol;Extracellular region or secreted;Nucleus
组织特异性
Belongs to the FBPase class 1 family.
疾病
Defects in FBP1 are the cause of fructose-1,6-bisphosphatase deficiency (FBPD) [MIM:229700]. FBPD is inherited as an autosomal recessive disorder mainly in the liver and causes life-threatening episodes of hypoglycemia and metabolic acidosis (lactacidemia) in newborn infants or young children.
相似性
Belongs to the FBPase class 1 family.
功能
Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain.
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