HMGA1 Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF,Flow-Cyt,ICC/IF | Bioss

bsm-61985R

重组兔单抗、mIHC精品抗体

HMGA1 Recombinant Rabbit mAb

高迁移率族蛋白A1重组兔单抗

HMG-R; HMGA1A; HMGIY; Hmga1b; Hmgi; Hmgy; HMGA1_HUMAN; HMGA1; HMG-I(Y); High mobility group AT-hook protein 1 (High mobility group protein A1); High mobility group protein R; HMGA1_MOUSE; HMGA1_RAT; high mobility group AT-hook 1; high-mobility group (nonhistone chromosomal) protein isoforms I and Y

Rabbit

A synthesized peptide derived from human HMGA1: 1-53

IgG

Liquid

affinity purified by Protein A

Recombinant

4F11

12 kDa

17 kDa

10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions.

HMGA1

High mobility group protein HMG-I/HMG-Y

Interacts with HIPK2 (By similarity). Interacts with HIV-1 pre-integration complex.

Nucleus. Chromosome.

Constitutively phosphorylated on two or three sites. Phosphorylated upon DNA damage, probably by ATM or ATR. Hyperphosphorylated at early stages of apoptosis, followed by dephosphorylation and methylation, which coincides with chromatin condensation. Isoforms HMG-I and HMG-Y can be phosphorylated by HIPK2. Phosphorylation of HMG-I at Ser-36, Thr-53 and Thr-78 and of HMG-Y at Thr-42 and Thr-67 by HIPK2 modulates DNA-binding affinity.
HMG-Y is not methylated.
Methylation at Arg-58 is mutually exclusive with methylation at Arg-60.

Note=A chromosomal aberration involving HMGA1 is found in pulmonary chondroid hamartoma. Translocation t(6;14)(p21;q23-24) with RAD51B.

Belongs to the HMGA family.
Contains 3 A.T hook DNA-binding domains.

HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions.