染色质解旋酶DNA结合蛋白重组兔单抗
Rrmab®兔单抗
货号：bsm-61977R
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概述
产品编号
bsm-61977R
产品类型
重组兔单抗
英文名称
CHD1L Recombinant Rabbit mAb
中文名称
染色质解旋酶DNA结合蛋白重组兔单抗
英文别名
ALC1; CHDL; 4432404A22Rik; Snf2p; CHD1L_HUMAN; CHD1L; Amplified in liver cancer protein 1; 3.6.4.-; CHD1L_MOUSE;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human CHD1L: 700-800
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
理论分子量
101
检测分子量
101
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
ATP-dependent chromatin remodeler that mediates chromatin-remodeling following DNA damage.Recruited to DNA damage sites through interaction with poly-ADP-ribose: specifically recognizes and binds histones that are poly-ADP-ribosylated on serine residues in response to DNA damage.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human, Mouse | 1:500-2000 | |
| Flow-Cyt | Human | Mouse | 1:50-100 |
| ICC/IF | Human, Mouse | 1:50-200 | |
| IP | Human, Mouse | 1:20-50 |
交叉反应
交叉反应: Human, Mouse
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靶标
基因名
CHD1L
蛋白名
Chromodomain-helicase-DNA-binding protein 1-like
亚基
Interacts with PARP1; interacts only when PARP1 is poly-ADP-ribosylated (PARylated).
亚细胞定位
Nucleus. Localizes at sites of DNA damage. Probably recruited to DNA damage sites by PARylated PARP1.
组织特异性
Frequently overexpressed in hepatomacellular carcinomas.
相似性
Belongs to the SNF2/RAD54 helicase family.
Contains 1 helicase ATP-binding domain.
Contains 1 helicase C-terminal domain.
Contains 1 Macro domain.
Contains 1 helicase ATP-binding domain.
Contains 1 helicase C-terminal domain.
Contains 1 Macro domain.
功能
DNA helicase which plays a role in chromatin-remodeling following DNA damage. Targeted to sites of DNA damage through interaction with poly(ADP-ribose) and functions to regulate chromatin during DNA repair. Able to catalyze nucleosome sliding in an ATP-dependent manner. Helicase activity is strongly stimulated upon poly(ADP-ribose)-binding.
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