CHD1L Recombinant Rabbit mAb (一抗) - WB,Flow-Cyt,ICC/IF,IP | Bioss

bsm-61977R

重组兔单抗

CHD1L Recombinant Rabbit mAb

染色质解旋酶DNA结合蛋白重组兔单抗

ALC1; CHDL; 4432404A22Rik; Snf2p; CHD1L_HUMAN; CHD1L; Amplified in liver cancer protein 1; 3.6.4.-; CHD1L_MOUSE; chromodomain helicase DNA binding protein 1 like; amplified in liver cancer 1

Rabbit

A synthesized peptide derived from human CHD1L: 700-800

IgG

Liquid

affinity purified by Protein A

Recombinant

9H4

101 kDa

110 kDa

10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

ATP-dependent chromatin remodeler that mediates chromatin-remodeling following DNA damage.Recruited to DNA damage sites through interaction with poly-ADP-ribose: specifically recognizes and binds histones that are poly-ADP-ribosylated on serine residues in response to DNA damage.

CHD1L

Chromodomain-helicase-DNA-binding protein 1-like

Interacts with PARP1; interacts only when PARP1 is poly-ADP-ribosylated (PARylated).

Nucleus. Localizes at sites of DNA damage. Probably recruited to DNA damage sites by PARylated PARP1.

Frequently overexpressed in hepatomacellular carcinomas.

Belongs to the SNF2/RAD54 helicase family.
Contains 1 helicase ATP-binding domain.
Contains 1 helicase C-terminal domain.
Contains 1 Macro domain.

DNA helicase which plays a role in chromatin-remodeling following DNA damage. Targeted to sites of DNA damage through interaction with poly(ADP-ribose) and functions to regulate chromatin during DNA repair. Able to catalyze nucleosome sliding in an ATP-dependent manner. Helicase activity is strongly stimulated upon poly(ADP-ribose)-binding.