SAE1 Recombinant Rabbit mAb (一抗) - WB,Flow-Cyt,ICC/IF,IP | Bioss
Rrmab?兔单抗
货号：bsm-61972R
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概述
产品编号
bsm-61972R
产品类型
重组兔单抗
英文名称
SAE1 Recombinant Rabbit mAb
中文名称
泛素样蛋白SUMO1激活酶重组兔单抗
英文别名
AOS1; HSPC140; SUA1; UBLE1A; 2400010M20Rik; 2610044L12Rik; D7Ertd177e; SAE1_BOVIN; SAE1; Ubiquitin-like 1-activating enzyme E1A; SAE1_HUMAN; SAE1_MOUSE; Ubl1a1; SAE1_RAT;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human SAE1: 201-248
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
5G12
理论分子量
38 kDa
检测分子量
42 kDa
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究领域
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | Rat | 1:500-2000 |
| Flow-Cyt | Human | Rat | 1:50-100 |
| ICC/IF | Human, Rat | 1:50-200 | |
| IP | Human, Rat | 1:20-50 |
交叉反应
交叉反应: Human (predicted: Rat)
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靶标
基因名
SAE1
蛋白名
SUMO-activating enzyme subunit 1
亚基
Heterodimer of SAE1 and UBA2/SAE2. The heterodimer corresponds to the two domains that are encoded on a single polypeptide chain in ubiquitin-activating enzyme E1. Interacts with UBE2I.
亚细胞定位
Nucleus.
组织特异性
Expression level increases during S phase and drops in G2 phase (at protein level).
翻译后修饰
Phosphorylated upon DNA damage, probably by ATM or ATR.
相似性
Belongs to the ubiquitin-activating E1 family.
功能
The heterodimer acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.
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