受体激活蛋白激酶C1重组兔单抗
Rrmab®兔单抗
货号：bsm-61942R
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概述
产品编号
bsm-61942R
产品类型
重组兔单抗
英文名称
RACK1 Recombinant Rabbit mAb
中文名称
受体激活蛋白激酶C1重组兔单抗
英文别名
C12-3; GNB2L1; c12.3; Gnb2-rs1; H12.3; HLC-7; PIG21; GB-like; p205; RACK1_CHICK; RACK1; Guanine nucleotide-binding protein subunit beta-like protein 12.3; Receptor for activated C kinase; Receptor of activated protein C kinase 1; Receptor of activated protein kinase C 1 (RACK1); RACK1_BOVIN; Guanine nucleotide-binding protein subunit beta-2-like 1; Receptor of activated protein kinase C 1; GBLP_MACFA; RACK1_HUMAN; Cell proliferation-inducing gene 21 protein; Human lung cancer oncogene 7 protein (HLC-7); RACK1_MOUSE; 12-3; RACK1_PIG; RACK1_RAT;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human RACK1: 250-317/317
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
9B3
理论分子量
35
检测分子量
35
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究领域
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
背景资料
Seems to bind protein kinase C acting as an intracellular receptor to anchor the activated PKC to the cytoskeleton. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| IHC-P | Human, Mouse, Rat | 1:100-500 | |
| IHC-F | Human, Mouse, Rat | 1:100-500 | |
| IF | Human, Mouse, Rat | 1:100-500 | |
| Flow-Cyt | Human, Mouse, Rat | 1:50-100 | |
| ICC/IF | Human | Mouse, Rat | 1:50-200 |
交叉反应
交叉反应: Human, Mouse, Rat
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靶标
基因名
RACK1
蛋白名
Receptor of activated protein C kinase 1
亚基
Component of the small (40S) ribosomal subunit. Exists as a monomer and also forms oligomers. Binds SLC9A3R1. Forms a ternary complex with TRIM63 and PRKCE. Interacts with HABP4, KRT1 and OTUB1. Interacts with SRC (via SH2 domain); the interaction is enhanced by tyrosine phosphorylation of GNB2L1/RACK1. Recruited in a circadian manner into a nuclear complex which also includes BMAL1 and PRKCA. Interacts with AR. Interacts with IGF1R but not with INSR. Interacts with ADAM12. Interacts with CLEC1B (via N-terminal region) and with HIF1A; the interaction promotes their degradation. Interacts with RHOA; this enhances RHOA activation and promotes cell migration. Interacts with CHRM2; the interaction regulates CHRM2 internalization. Interacts with TRPM6 (via kinase domain). Interacts with PTK2/FAK1; required for PTK2/FAK1 phosphorylation and dephosphorylation. Interacts with FLT1. Interacts with TBXA2R isoform 2. Interacts with HRAS. Interacts with Y.pseudotuberculosis yopK. Interacts with a number of viral proteins including Epstein-Barr virus BZLF1 and HIV-1 Nef; interaction with Nef increases Nef phosphorylation by PKC.
亚细胞定位
Cell membrane; Peripheral membrane protein. Cytoplasm. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Nucleus. Perikaryon. Cell projection, dendrite. Cell projection, phagocytic cup.
组织特异性
In the liver, expressed at higher levels in activated hepatic stellate cells than in hepatocytes or Kupffer cells. Up-regulated in hepatocellular carcinomas and in the adjacent non-tumor liver tissue.
相似性
Belongs to the WD repeat G protein beta family.
Contains 7 WD repeats.
Contains 7 WD repeats.
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