HIF1AN Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF,Flow-Cyt,ICC/IF | Bioss

Name: 缺氧诱导因子1α抑制蛋白/HIF1AN重组兔单抗（HIF1AN Recombinant Rabbit mAb）
Brand: 北京博奥森生物科技有限公司
SKU: bsm-61905R
Availability: InStock

Rrmab^?兔单抗

2026-07-01~2026-08-31，AB2607A 京东卡2026-07-01~2026-08-31，AB2607B 豪礼卡

一键复制说明书

货号：bsm-61905R

产品详情

概述

产品编号

bsm-61905R

产品类型

重组兔单抗、mIHC精品抗体

英文名称

HIF1AN Recombinant Rabbit mAb

中文名称

缺氧诱导因子1α抑制蛋白/HIF1AN重组兔单抗

英文别名

FIH1; Q5W147_HUMAN; HIF1N_HUMAN; HIF1AN; Factor inhibiting HIF-1 (FIH-1); Hypoxia-inducible factor asparagine hydroxylase; 1.14.11.30; 1.14.11.n4; hypoxia inducible factor 1 subunit alpha inhibitor; Peptide-aspartate beta-dioxygenase

抗体来源

Rabbit

免疫原

A synthesized peptide derived from human HIF 1 alpha inhibitor: 1-58/349

亚型

IgG

性状

Liquid

纯化方法

affinity purified by Protein A

克隆类型

Recombinant

克隆号

4B9

理论分子量

40 kDa

检测分子量

40 kDa

储存液

10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

研究领域

Cancer > Invasion/microenvironment > Hypoxia > HIF

Cancer > Invasion/microenvironment > Hypoxia > Hydroxylases

Epigenetics and Nuclear Signaling > Cardiovascular/Immune > Hypoxia > HIF

Epigenetics and Nuclear Signaling > Chromatin Modifying Enzymes > Jumonji containing proteins

Epigenetics and Nuclear Signaling > Chromatin Modifying Enzymes > Methylation

SWISS

Q5W147

Gene ID

55662

保存条件

Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.

注意事项

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

数据库链接

Unigene : BC007719 Human

Entrez Gene : 55662 Human

IMAGE Id : 4138066 Human

Omim : 606615 Human

SwissProt : Q5W147 Human

SwissProt : Q9NWT6 Human

Unigene : 500788 Human

背景资料

Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins.

基因名

HIF1AN

蛋白名

Hypoxia-inducible factor 1-alpha inhibitor

亚基

Homodimer; homodimerization is essential for catalyticactivity. Interacts with VHL and HIF1A. Part of a complex with VHL,HIF1A and HDAC1 or HDAC2 or HDAC3. Interacts with NFKB1 and NFKBIA.Interacts with NOTCH1, NOTCH2 and NOTCH3 but not with NOTCH4.Interacts with APBA3; binding inhibits HIF1AN binding to HIF1A.Interacts with TNKS2. Interacts with PPP1R12A. Interacts with ASB4(By similarity). Interacts with UBE3A.

亚细胞定位

Nucleus. Cytoplasm. Cytoplasm, perinuclearregion. Note=Mainly cytoplasmic localization, but interaction withNOTCH1 results in nuclear localization and interaction with ABPA3results in perinuclear localization in macrophages.

相似性

Contains 1 JmjC domain.

功能

Hydroxylates HIF-1 alpha at 'Asp-803' in the C-terminaltransactivation domain (CAD). Functions as an oxygen sensor and,under normoxic conditions, the hydroxylation prevents interactionof HIF-1 with transcriptional coactivators includingCbp/p300-interacting transactivator. Involved in transcriptionalrepression through interaction with HIF1A, VHL and histonedeacetylases. Hydroxylates specific Asn residues within ankyrinrepeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A andseveral other ARD-containing proteins. Also hydroxylates Asp andHis residues within ARDs of ANK1 and TNKS2, respectively.Negatively regulates NOTCH1 activity, accelerating myogenicdifferentiation. Positively regulates ASB4 activity, promotingvascular differentiation.