缺氧诱导因子1α抑制蛋白/HIF1AN重组兔单抗
Rrmab®兔单抗
货号：bsm-61905R
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概述
产品编号
bsm-61905R
产品类型
重组兔单抗、mIHC精品抗体
英文名称
HIF1AN Recombinant Rabbit mAb
中文名称
缺氧诱导因子1α抑制蛋白/HIF1AN重组兔单抗
英文别名
FIH1; Q5W147_HUMAN; HIF1N_HUMAN; HIF1AN; Factor inhibiting HIF-1 (FIH-1); Hypoxia-inducible factor asparagine hydroxylase; 1.14.11.30; 1.14.11.n4;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human HIF 1 alpha inhibitor: 1-58/349
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
4B9
理论分子量
40
检测分子量
40
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究领域
Cancer > Invasion/microenvironment > Hypoxia > HIF
Cancer > Invasion/microenvironment > Hypoxia > Hydroxylases
Epigenetics and Nuclear Signaling > Cardiovascular/Immune > Hypoxia > HIF
Epigenetics and Nuclear Signaling > Chromatin Modifying Enzymes > Jumonji containing proteins
Epigenetics and Nuclear Signaling > Chromatin Modifying Enzymes > Methylation
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | 1:500-2000 | |
| IHC-P | Human | 1:200-500 | |
| IHC-F | Human | 1:200-500 | |
| IF | Human | 1:200-500 | |
| Flow-Cyt | Human | 1ug/test | |
| ICC/IF | Human | 1:100-200 |
交叉反应
交叉反应: Human
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靶标
基因名
HIF1AN
蛋白名
Hypoxia-inducible factor 1-alpha inhibitor
亚基
Homodimer; homodimerization is essential for catalyticactivity. Interacts with VHL and HIF1A. Part of a complex with VHL,HIF1A and HDAC1 or HDAC2 or HDAC3. Interacts with NFKB1 and NFKBIA.Interacts with NOTCH1, NOTCH2 and NOTCH3 but not with NOTCH4.Interacts with APBA3; binding inhibits HIF1AN binding to HIF1A.Interacts with TNKS2. Interacts with PPP1R12A. Interacts with ASB4(By similarity). Interacts with UBE3A.
亚细胞定位
Nucleus. Cytoplasm. Cytoplasm, perinuclearregion. Note=Mainly cytoplasmic localization, but interaction withNOTCH1 results in nuclear localization and interaction with ABPA3results in perinuclear localization in macrophages.
相似性
Contains 1 JmjC domain.
功能
Hydroxylates HIF-1 alpha at 'Asp-803' in the C-terminaltransactivation domain (CAD). Functions as an oxygen sensor and,under normoxic conditions, the hydroxylation prevents interactionof HIF-1 with transcriptional coactivators includingCbp/p300-interacting transactivator. Involved in transcriptionalrepression through interaction with HIF1A, VHL and histonedeacetylases. Hydroxylates specific Asn residues within ankyrinrepeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A andseveral other ARD-containing proteins. Also hydroxylates Asp andHis residues within ARDs of ANK1 and TNKS2, respectively.Negatively regulates NOTCH1 activity, accelerating myogenicdifferentiation. Positively regulates ASB4 activity, promotingvascular differentiation.
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