FRCP2; irisin; 1500001L03Rik; PeP; Pxp; FNDC5_HUMAN; FNDC5; Fibronectin type III repeat-containing protein 2; FNDC5_MOUSE; Peroxisomal protein (PeP); FNDC5_RAT;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human FNDC5: 50-100/212
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
5B5
理论分子量
24
检测分子量
24
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
Contrary to mouse, may not be involved in the beneficial effects of muscular exercise, nor in the induction of browning of human white adipose tissue.
产品应用
应用
已检合格种属
预测种属
推荐稀释比例
WB
Mouse, Rat
Human
1:500-2000
交叉反应
交叉反应: Human, Mouse, Rat
相关产品
暂无相关产品
靶标
基因名
FNDC5
蛋白名
Fibronectin type III domain-containing protein 5
亚细胞定位
Cell membrane; Single-pass type I membrane protein. Peroxisome membrane; Single-pass type I membrane protein. Note=Imported in peroxisomes through the PEX5 receptor pathway. Irisin: Secreted. Note=Detected in the blood of individuals subjected to endurance exercise.
翻译后修饰
The extracellular domain is cleaved and released from the cell membrane. N-Glycosylated.
相似性
Contains 1 fibronectin type-III domain.
功能
Irisin: mediates beneficial effects of muscular exercise. Induces browning of white adipose tissue by stimulating UCP1 expression, at least in part, via the nuclear receptor PPARA.