SF3B1 Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,ICC/IF,IF | Bioss

bsm-61871R

重组兔单抗

SF3B1 Recombinant Rabbit mAb

选择性剪接因子3B亚基1重组兔单抗

SF3B1_HUMAN; SF3B1; Pre-mRNA-splicing factor SF3b 155 kDa subunit (SF3b155); Spliceosome-associated protein 155 (SAP 155); SAP155; Hsh155; MDS; PRP10; PRPF10; SF3b155; splicing factor 3b subunit 1; splicing factor 3b, subunit 1, 155kD; splicing factor 3b, subunit 1, 155kDa

Rabbit

A synthesized peptide derived from human SF3B1: 1-53/1304

IgG

Liquid

affinity purified by Protein A

Recombinant

5F6

146 kDa

155 kDa

10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs.

SF3B1

Splicing factor 3B subunit 1

Identified in the spliceosome C complex. Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Component of splicing factor SF3B which is composed of at least eight subunits; SF3B1/SAP155/SF3B155, SF3B2/SAP145/SF3B155, SF3B3/SAP130/SF3B130, SF3B4/SAP49/SF3B49, SF3B14A, PHF5A/SF3B14B, SF3B10 and SF3B125. Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A and DDX21. SF3B associates with the splicing factor SF3A and a 12S RNA unit to form the U2 small nuclear ribonucleoproteins complex (U2 snRNP). SF3B1 interacts directly with the splicing factor U2AF. Phosphorylated form interacts with PPP1R8.

Nucleus speckle. Note=During mitosis, transiently dispersed from the nuclear speckles to the cytoplasm.

Phosphorylated. Phosphorylation occurs concomitantly with the splicing catalytic steps. Phosphorylation on Thr-244, Thr-248 and Thr-313 by cyclin-dependent kinases promotes interaction with PPP1R8 during mitosis.

Belongs to the SF3B1 family.
Contains 11 HEAT repeats.

SF3B1 is subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. The carboxy-terminal two-thirds of subunit 1 have 22 non-identical, tandem HEAT repeats that form rod-like, helical structures.