GIT1 Recombinant Rabbit mAb (一抗) - WB,Flow-Cyt | Bioss

bsm-61866R

重组兔单抗

GIT1 Recombinant Rabbit mAb

G蛋白偶联受体激酶相互作用蛋白1重组兔单抗

p95-APP1; Cat-1; p95Cat; GIT1_HUMAN; GIT1; ARF GAP GIT1; Cool-associated and tyrosine-phosphorylated protein 1 (CAT-1 | CAT1); G protein-coupled receptor kinase-interactor 1; GRK-interacting protein 1; GIT1_MOUSE; GIT1_RAT; GRK-interactor 1; GIT ArfGAP 1; G protein-coupled receptor kinase interactor 1; G protein-coupled receptor kinase interacting ArfGAP 1

Rabbit

A synthesized peptide derived from human GIT1: 150-200/761

IgG

Liquid

affinity purified by Protein A

Recombinant

7F1

84 kDa

100 kDa

10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

GTPase-activating protein for ADP ribosylation factor family members, including ARF1. Multidomain scaffold protein that interacts with numerous proteins and therefore participates in many cellular functions, including receptor internalization, focal adhesion remodeling, and signaling by both G protein-coupled receptors and tyrosine kinase receptors.Through PAK1 activation, positively regulates microtubule nucleation during interphase.

GIT1

ARF GTPase-activating protein GIT1

Cytoplasm. Cycles between at least 3 distinct intracellular compartments, including focal adhesions, cytoplasmic complexes and membrane protrusions. During cell migration, when cells detach, moves from the adhesions into the cytoplasmic complexes towards the leading edge, while, when cells adhere, it is found in vinculin-containing adhesions. Recruitment to adhesions may be mediated by active tyrosine-phosphorylated paxillin.

Phosphorylated on tyrosine residues by PTK2 and SRC in growing fibroblasts. Tyrosine-phosphorylation is increased following cell spreading on fibronectin, decreased in cells arrested in mitosis and increased in the ensuing G1 phase.

Contains 3 ANK repeats.
Contains 1 Arf-GAP domain.

GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. Increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia. Sequesters inactive non-tyrosine-phosphorylated paxillin in cytoplasmic complexes.