G蛋白偶联受体激酶相互作用蛋白1重组兔单抗
Rrmab®兔单抗
货号：bsm-61866R
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概述
产品编号
bsm-61866R
产品类型
重组兔单抗
英文名称
GIT1 Recombinant Rabbit mAb
中文名称
G蛋白偶联受体激酶相互作用蛋白1重组兔单抗
英文别名
p95-APP1; Cat-1; p95Cat; GIT1_HUMAN; GIT1; ARF GAP GIT1; Cool-associated and tyrosine-phosphorylated protein 1 (CAT-1 | CAT1); G protein-coupled receptor kinase-interactor 1; GRK-interacting protein 1; GIT1_MOUSE; GIT1_RAT; GRK-interactor 1;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human GIT1: 150-200/761
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
理论分子量
84
检测分子量
84
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究领域
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
GTPase-activating protein for ADP ribosylation factor family members, including ARF1. Multidomain scaffold protein that interacts with numerous proteins and therefore participates in many cellular functions, including receptor internalization, focal adhesion remodeling, and signaling by both G protein-coupled receptors and tyrosine kinase receptors.Through PAK1 activation, positively regulates microtubule nucleation during interphase.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | Mouse, Rat | 1:500-2000 |
| Flow-Cyt | Human | Mouse, Rat | 1:50-100 |
交叉反应
交叉反应: Human, Mouse, Rat
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靶标
基因名
GIT1
蛋白名
ARF GTPase-activating protein GIT1
亚细胞定位
Cytoplasm. Cycles between at least 3 distinct intracellular compartments, including focal adhesions, cytoplasmic complexes and membrane protrusions. During cell migration, when cells detach, moves from the adhesions into the cytoplasmic complexes towards the leading edge, while, when cells adhere, it is found in vinculin-containing adhesions. Recruitment to adhesions may be mediated by active tyrosine-phosphorylated paxillin.
翻译后修饰
Phosphorylated on tyrosine residues by PTK2 and SRC in growing fibroblasts. Tyrosine-phosphorylation is increased following cell spreading on fibronectin, decreased in cells arrested in mitosis and increased in the ensuing G1 phase.
相似性
Contains 3 ANK repeats.
Contains 1 Arf-GAP domain.
Contains 1 Arf-GAP domain.
功能
GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. Increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia. Sequesters inactive non-tyrosine-phosphorylated paxillin in cytoplasmic complexes.
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