FGF1 Recombinant Rabbit mAb (一抗) - WB | Bioss

bsm-61826R

重组兔单抗

FGF1 Recombinant Rabbit mAb

酸性成纤维细胞生长因子重组兔单抗

AFGF; ECGF; ECGF-beta; ECGFA; ECGFB; FGF-1; FGF-alpha; FGFA; GLIO703; HBGF-1; HBGF1; Fgf2b; Dffrx; Fam; FGF1_HUMAN; FGF1; Acidic fibroblast growth factor (aFGF); Endothelial cell growth factor (ECGF); Heparin-binding growth factor 1 (HBGF-1); FGF1_RAT; FGF1_MOUSE; fibroblast growth factor 1; fibroblast growth factor 1 (acidic); heparin-binding growth factor 1; endothelial cell growth factor, alpha; endothelial cell growth factor, beta

Rabbit

A synthesized peptide derived from human FGF1: 130-155

IgG

Liquid

affinity purified by Protein A

Recombinant

6H8

17 kDa

15 kDa

10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

生长因子和激素（ Growth Factor and Hormones）
肝素结合生长因子(FGF1)可与肝素结合是血管生成剂，还是多种细胞强的促细胞分裂剂，可刺激多种中胚层细胞的生长包括软骨细胞、粒细胞和内皮细胞，在创伤愈合及动物肢体再生中可能起作用。在不同的组织中分布和含量不同，以单体形式存在，属于肝素结合生长因子家族成员之一。

Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as a potent mitogen in vitro.

FGF1

Fibroblast growth factor 1

Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Found in a complex with FGFBP1, FGF1 and FGF2. Interacts with FGFBP1. Part of a Cu(2+)-dependent multiprotein aggregate containing FGF1, S100A13 and SYT1. Interacts with SYT1. Interacts with S100A13. Interacts with LRRC59. Interacts with CSNKA, CSNKB and FIBP. While binding with LRRC59, CSNKA and FIBP seem mutually exclusive, CSNKB and FIBP may cooperatively interact with FGF1.

Secreted. Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytosol. Nucleus. Note=Lacks a cleavable signal sequence. Within the cytoplasm, it is transported to the cell membrane and then secreted by a non-classical pathway that requires Cu(2+) ions and S100A13. Secreted in a complex with SYT1 (By similarity). Binding of exogenous FGF1 to FGFR facilitates endocytosis followed by translocation of FGF1 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as LRRC59.

Predominantly expressed in kidney and brain. Detected at much lower levels in heart and skeletal muscle.

In the nucleus, phosphorylated by PKC/PRKCD.

Belongs to the heparin-binding growth factors family.

The heparin-binding fibroblast growth factors play important roles in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. They are potent mitogens in vitro.