Acts as a component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.
产品应用
应用
已检合格种属
预测种属
推荐稀释比例
WB
Human, Mouse
Rat
1:500-2000
ICC/IF
Human, Mouse, Rat
1:50-200
IP
Human, Mouse, Rat
1:20-50
交叉反应
交叉反应: Human, Mouse (predicted: Rat)
相关产品
暂无相关产品
靶标
基因名
VPS26A
蛋白名
Vacuolar protein sorting-associated protein 26A
亚细胞定位
Cytoplasm. Endosome membrane.
相似性
Belongs to the VPS26 family.
功能
Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA).