肌钙集蛋白/收钙素重组兔单抗
Rrmab®兔单抗
货号：bsm-61791R
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概述
产品编号
bsm-61791R
产品类型
重组兔单抗
英文名称
Calsequestrin Recombinant Rabbit mAb
中文名称
肌钙集蛋白/收钙素重组兔单抗
英文别名
CASQ; CSQ1; PDIB1; VMCQA; CSQ; CSQ-1; sCSQ; CASQ1_HUMAN; CASQ1; Calmitine; Calsequestrin, skeletal muscle isoform; CASQ1_MOUSE; CASQ1_RAT; Aspartactin; Laminin-binding protein;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human Calsequestrin 1: 100-150/396
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
11G3
理论分子量
45
检测分子量
63
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
肌钙集蛋白，隐钙素，收钙素，是肌浆网上调控钙储存的主要结合蛋白。CASQ与内质网钙结合蛋白肌钙网蛋白具有同源性（calreticulin）。CASQ1主要在快收缩骨骼肌表达，CASQ2主要在在慢收缩骨骼肌和心肌表达。
背景资料
Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. The release of calcium bound to calsequestrin through a calcium release channel triggers muscle contraction. Binds 40 to 50 moles of calcium. Also binds laminin.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| IHC-P | Human, Mouse, Rat | 1:50-200 | |
| IHC-F | Human, Mouse, Rat | 1:50-200 | |
| IF | Human, Mouse, Rat | 1:50-200 | |
| Flow-Cyt | Human, Mouse, Rat | 1:50-100 |
交叉反应
交叉反应: Human, Mouse, Rat
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靶标
基因名
CASQ1
蛋白名
Calsequestrin-1
亚细胞定位
Sarcoplasmic reticulum lumen. Mitochondrion. Note=This isoform of calsequestrin occurs in the sarcoplasmic reticulum's terminal cisternae luminal spaces of fast skeletal muscle cells. Also mitochondrial according to PubMed:7945294.
相似性
Belongs to the calsequestrin family.
功能
Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. The release of calcium bound to calsequestrin through a calcium release channel triggers muscle contraction. The skeletal muscle isoform (CASQ1) binds around 80 Ca(2+) ions, while the cardiac isoform (CASQ2) binds approximately 60 Ca(2+).
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