MCT1 Recombinant Rabbit mAb (一抗) - WB | Bioss

bsm-61785R

重组兔单抗

MCT1 Recombinant Rabbit mAb

单羧酸转运蛋白-1重组兔单抗

HHF7; MCT; MCT1; MCT1D; MOT1_HUMAN; SLC16A1; MCT 1; Solute carrier family 16 member 1; MOT1_MOUSE; solute carrier family 16 (monocarboxylic acid transporters), member 1; solute carrier family 16, member 1 (monocarboxylic acid transporter 1); solute carrier family 16 (monocarboxylate transporter), member 1; Monocarboxylate transporter 1

Rabbit

A synthesized peptide derived from human MCT 1: 440-500/500

IgG

Liquid

affinity purified by Protein A

Recombinant

9G12

54 kDa

50 kDa

10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

单羧酸转运蛋白家族是哺乳动物细胞膜上一类重要的跨膜转运蛋白,负责乳酸、短链脂肪酸等单羧酸类化合物的跨膜转运,有促进营养物质吸收、代谢动态的平衡、调节胞内pH值以及参与药物输送等多种生物学功能。

Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate.

SLC16A1

Monocarboxylate transporter 1

Cell membrane; Multi-pass membrane protein.

Widely expressed in normal and in cancer cells.

Defects in SLC16A1 are the cause of symptomatic deficiency in lactate transport (SDLT) [MIM:245340]; also known as erythrocyte lactate transporter defect. Deficiency of lactate transporter may result in an acidic intracellular environment created by muscle activity with consequent degeneration of muscle and release of myoglobin and creatine kinase. This defect might compromise extreme performance in otherwise healthy individuals.
Defects in SLC16A1 are the cause of familial hyperinsulinemic hypoglycemia type 7 (HHF7) [MIM:610021]; also known as exercise-induced hyperinsulinemic hypoglycemia. HHF7 is a dominantly inherited hypoglycemic disorder characterized by inappropriate insulin secretion during anaerobic exercise or on pyruvate load.

Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.

Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate.