组蛋白去甲基化酶JARID1A重组兔单抗
Rrmab®兔单抗
货号：bsm-61779R
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概述
产品编号
bsm-61779R
产品类型
重组兔单抗
英文名称
KDM5A Recombinant Rabbit mAb
中文名称
组蛋白去甲基化酶JARID1A重组兔单抗
英文别名
KDM5A_HUMAN; KDM5A; Histone demethylase JARID1A; Jumonji/ARID domain-containing protein 1A; Retinoblastoma-binding protein 2 (RBBP-2); [histone H3]-trimethyl-L-lysine(4) demethylase 5A; 1.14.11.67; JARID1A; RBBP2; RBP2; KDM5A_MOUSE;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human KDM5A: 1400-1690
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
4G2
理论分子量
192
检测分子量
192
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究领域
Epigenetics and Nuclear Signaling > Chromatin Modifying Enzymes > Jumonji containing proteins
Epigenetics and Nuclear Signaling > Nuclear Signaling Pathways > Nuclear Receptors > Co-activators/co-repressors
Epigenetics and Nuclear Signaling > Transcription > Co-factors
Epigenetics and Nuclear Signaling > Transcription > Other factors
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | Mouse | 1:500-2000 |
| Flow-Cyt | Human, Mouse | 1:50-100 | |
| ICC/IF | Human | Mouse | 1:50-200 |
| IP | Human, Mouse | 1:20-50 |
交叉反应
交叉反应: Human (predicted: Mouse)
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靶标
基因名
KDM5A
蛋白名
Lysine-specific demethylase 5A
亚细胞定位
Nucleus > nucleolus. Occupies promoters of genes involved in RNA metabolism and mitochondrial function.
相似性
Belongs to the JARID1 histone demethylase family.
Contains 1 ARID domain.
Contains 1 JmjC domain.
Contains 1 JmjN domain.
Contains 3 PHD-type zinc fingers.
Contains 1 ARID domain.
Contains 1 JmjC domain.
Contains 1 JmjN domain.
Contains 3 PHD-type zinc fingers.
功能
Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May stimulate transcription mediated by nuclear receptors. May be involved in transcriptional regulation of Hox proteins during cell differentiation. May participate in transcriptional repression of cytokines such as CXCL12.
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