胰岛素样生长因子2mRNA结合蛋白3重组兔单抗
Rrmab®兔单抗
货号：bsm-61766R
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概述
产品编号
bsm-61766R
产品类型
重组兔单抗、mIHC精品抗体
英文名称
IMP3 Recombinant Rabbit mAb
中文名称
胰岛素样生长因子2mRNA结合蛋白3重组兔单抗
英文别名
CT98; IMP-3; IMP3; KOC; KOC1; VICKZ3; 2610101N11Rik; Koc13; Neilsen; mimp3; Ab2-255; RGD1306512; IF2B3_HUMAN; IGF2BP3; IGF2 mRNA-binding protein 3; IGF-II mRNA-binding protein 3; KH domain-containing protein overexpressed in cancer (hKOC); VICKZ family member 3; IF2B3_MOUSE; mIMP-3;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human IMP 3: 1-200
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
3D10
理论分子量
64
检测分子量
69
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究领域
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
IGF2BP3是一种可以与胰岛素样生长因子(IGFs)结合的分泌性蛋白,其通过IGFs调节细胞的生长、分化、凋亡、黏附和运动,IGF2BP3与IGFs结合可以调节IGFs与IGF2型受体间的相互作用,改变其促有丝分裂效应、凋亡抑制效应和促细胞运动作用。
背景资料
RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | 1:500-2000 | |
| IHC-P | Human | 1:50-200 | |
| IHC-F | Human | 1:50-200 | |
| IF | Human | 1:50-200 | |
| Flow-Cyt | Human | 1:50-100 | |
| ICC/IF | Human | 1:50-200 | |
| IP | Human | 1:20-50 |
交叉反应
交叉反应: Human
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靶标
基因名
IGF2BP3
蛋白名
Insulin-like growth factor 2 mRNA-binding protein 3
亚基
Homodimer and multimer. Interacts with IGF2BP1.
亚细胞定位
Nucleus. Cytoplasm. Note=Found in lamellipodia of the leading edge, in the perinuclear region, and beneath the plasma membrane. The subcytoplasmic localization is cell specific and regulated by cell contact and growth. Localized at the connecting piece and the tail of the spermatozoa. Colocalized with CD44 mRNA in RNP granules.
组织特异性
Expressed in fetal liver, fetal lung, fetal kidney, fetal thymus, fetal placenta, fetal follicles of ovary and gonocytes of testis, growing oocytes, spermatogonia and semen (at protein level). Expressed in cervix adenocarcinoma, in testicular, pancreatic and renal-cell carcinomas (at protein level). Expressed ubiquitously during fetal development at 8 and 14 weeks of gestation. Expressed in ovary, testis, brain, placenta, pancreatic cancer tissues and pancreatic cancer cell lines.
相似性
Belongs to the RRM IMP/VICKZ family.
Contains 4 KH domains.
Contains 2 RRM (RNA recognition motif) domains.
Contains 4 KH domains.
Contains 2 RRM (RNA recognition motif) domains.
功能
RNA-binding protein that act as a regulator of mRNA translation and stability. Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binds to sequences in the 3'-UTR of CD44 mRNA.
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