造血转录因子PU.1重组兔单抗

Rrmab®兔单抗
2026-01-04~2026-02-28,RR26012026-01-04~2026-02-28,TR
造血转录因子PU.1重组兔单抗
货号:bsm-61756R
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概述

产品编号
bsm-61756R
产品类型
重组兔单抗
英文名称
PU.1/Spi1 Recombinant Rabbit mAb
中文名称
造血转录因子PU.1重组兔单抗
英文别名
AGM10; OF; PU.1; SFPI1; SPI-1; SPI-A; SPI1_HUMAN; SPI1; 31 kDa-transforming protein;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human SPI1: 1-50/270
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
7D6
理论分子量
31
检测分子量
42
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
背景资料
Pioneer transcription factor, which controls hematopoietic cell fate by decompacting stem cell heterochromatin and allowing other transcription factors to enter otherwise inaccessible genomic sites. Once in open chromatin, can directly control gene expression by binding genetic regulatory elements and can also more broadly influence transcription by recruiting transcription factors, such as interferon regulatory factors (IRFs), to otherwise inaccessible genomic regions.
造血转录因子PU.1重组兔单抗

产品应用

应用已检合格种属预测种属推荐稀释比例
WBHuman, Mouse1:500-2000

交叉反应

交叉反应: Human, Mouse

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靶标

基因名
SPI1
蛋白名
Transcription factor PU.1
亚基
Binds DNA as a monomer. Interacts with CEBPD and NONO (By similarity). Interacts with RUNX1 and SPIB. Interacts with GFI1; the interaction represses SPI1 transcriptional activity.
亚细胞定位
Nucleus.
相似性
Belongs to the ETS family.
Contains 1 ETS DNA-binding domain.
功能
Binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. This protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or B-cells. Also binds RNA and may modulate pre-mRNA splicing.

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