Pioneer transcription factor, which controls hematopoietic cell fate by decompacting stem cell heterochromatin and allowing other transcription factors to enter otherwise inaccessible genomic sites. Once in open chromatin, can directly control gene expression by binding genetic regulatory elements and can also more broadly influence transcription by recruiting transcription factors, such as interferon regulatory factors (IRFs), to otherwise inaccessible genomic regions.
产品应用
应用
已检合格种属
预测种属
推荐稀释比例
WB
Human, Mouse
1:500-2000
交叉反应
交叉反应: Human, Mouse
相关产品
暂无相关产品
靶标
基因名
SPI1
蛋白名
Transcription factor PU.1
亚基
Binds DNA as a monomer. Interacts with CEBPD and NONO (By similarity). Interacts with RUNX1 and SPIB. Interacts with GFI1; the interaction represses SPI1 transcriptional activity.
亚细胞定位
Nucleus.
相似性
Belongs to the ETS family.
Contains 1 ETS DNA-binding domain.
功能
Binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. This protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or B-cells. Also binds RNA and may modulate pre-mRNA splicing.