Nkx3.1 Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF | Bioss

bsm-61752R

重组兔单抗

Nkx3.1 Recombinant Rabbit mAb

转录因子同源蛋白Nkx3.1重组兔单抗

BAPX2; NKX3; NKX3.1; NKX3A; Bax; Nkx-3.1; bagpipe; NKX31_HUMAN; NKX3-1; Homeobox protein NK-3 homolog A; NKX31_MOUSE; NK3 homeobox 1; NK homeobox (Drosophila), family 3, A; NK3 transcription factor related, locus 1 (Drosophila)

Rabbit

A synthesized peptide derived from human Nkx 3.1: 1-234

IgG

Liquid

affinity purified by Protein A

Recombinant

5D10

26 kDa

28 kDa

10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells.

NKX3-1

Homeobox protein Nkx-3.1

Interacts with serum response factor (SRF) (By similarity). Interacts with SPDEF. Interacts with WDR77. Interacts with TOPORS which polyubiquitinates NKX3-1 and induces its proteasomal degradation.

Nucleus.

Highly expressed in the prostate and, at a lower level, in the testis.

Ubiquitinated by TOPORS; monoubiquitinated at several residues and also polyubiquitinated on single residues.

Belongs to the NK-3 homeobox family.
Contains 1 homeobox DNA-binding domain.

Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Play an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Act as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells.