胰岛素样生长因子结合蛋白7重组兔单抗
Rrmab®兔单抗
货号：bsm-61734R
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概述
产品编号
bsm-61734R
产品类型
重组兔单抗
英文名称
IGFBP7 Recombinant Rabbit mAb
中文名称
胰岛素样生长因子结合蛋白7重组兔单抗
英文别名
AGM; FSTL2; IBP-7; IGFBP-7; IGFBP-7v; IGFBPRP1; MAC25; PSF; RAMSVPS; TAF; IGFBP-RP-1; IGFBP-rP1; IBP7_HUMAN; IGFBP7; IGF-binding protein 7; MAC25 protein; PGI2-stimulating factor; Prostacyclin-stimulating factor; Tumor-derived adhesion factor (TAF); IBP7_MOUSE;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human IBP 7: 100-200
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
12A15
理论分子量
29
检测分子量
29
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | Mouse, Rat | 1:500-2000 |
| IHC-P | Mouse, Rat | Human | 1:100-500 |
| IHC-F | Mouse, Rat | Human | 1:100-500 |
| IF | Mouse, Rat | Human | 1:100-500 |
| Flow-Cyt | Human | Mouse, Rat | 1ug/Test |
| ICC/IF | Human, Mouse, Rat | 1:50-200 |
交叉反应
交叉反应: Human, Mouse, Rat
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靶标
基因名
IGFBP7
蛋白名
Insulin-like growth factor-binding protein 7
亚基
May interact with VPS24/CHMP3; the relevance of such interaction however remains unclear.
亚细胞定位
Secreted.
翻译后修饰
N-glycosylated.
疾病
Defects in IGFBP7 are the cause of retinal arterial macroaneurysm with supravalvular pulmonic stenosis (RAMSVPS) [MIM:614224]. RAMSVPS is an autosomal recessive condition characterized by the bilateral appearance of 'beading' along the major retinal arterial trunks, with the subsequent formation of macroaneurysms. Affected individuals also have supravalvular pulmonic stenosis, often requiring surgical correction.
相似性
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.Contains 1 IGFBP N-terminal domain.Contains 1 Kazal-like domain.
功能
Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion.
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