NUMA1 Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF,Flow-Cyt,ICC/IF,ELISA | Bioss

bsm-61733R

重组兔单抗

NUMA1 Recombinant Rabbit mAb

核有丝分裂器NuMA蛋白重组兔单抗

NMP-22; NUMA; NUMA1_HUMAN; NUMA1; Nuclear matrix protein-22 (NMP-22); Nuclear mitotic apparatus protein (NuMA protein); SP-H antigen; NMP22; nuclear mitotic apparatus protein 1

Rabbit

KLH conjugated synthetic peptide derived from human NUMA1

IgG

Liquid

affinity purified by Protein A

Recombinant

10G4

238 kDa

238 kDa

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

NuMA (Nuclear mitotic apparatus protein)是细胞核基质中的一种高分子量蛋白质，具有一个特殊的细胞周期依赖性.核有丝分裂器蛋白NuMA与人类肿瘤细胞的恶性增殖相关.

Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division.Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles

NUMA1

Nuclear mitotic apparatus protein 1

Homodimer. Also forms multiarm oligomers by association of C-terminal tail domains, oligomers may further assemble to form a hexagonal nuclear lattice-like network. Interacts with TNKS.

Nucleus matrix. Chromosome. Cytoplasm, cytoskeleton, spindle pole. Note=Resides in the nuclear matrix during interphases. Dissociates from condensing chromosomes during early prophase, and relocates to the spindle poles via dynein/dynamin association, it remain there until the anaphase onset. Before the complete disintegration of the nuclear lamina. As mitosis progresses it reassociates with telophase chromosomes very early during nuclear reformation, before substantial accumulation of lamins on chromosomal surfaces is evident.
Isoform Numa-m: Cytoplasm. Note=Mainly clustered at the centrosomal region.
Isoform Numa-s: Cytoplasm. Note=Mainly clustered at the centrosomal region.

ADP-ribosylated by TNKS during mitosis.
Phosphorylated in the C-terminal tail during mitosis, probably by CDK1. Phosphorylation increases solubility and promotes association with dynein and subsequent translocation to the spindle poles.

Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority if the nuclear volume. Required for maintenance and establishment of the mitotic spindle poles, functionning as a tether linking bulk microtubules of the spindle to centrosomes. May be involved in coordination of the alignment of the mitotic spindle to the cellular polarity axis, which is a prerequisite for asymmetric cell divisions.