CYP1A2重组兔单抗
Rrmab®兔单抗
货号：bsm-61730R
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概述
产品编号
bsm-61730R
产品类型
重组兔单抗
英文名称
CYP1A2 Recombinant Rabbit mAb
中文名称
CYP1A2重组兔单抗
英文别名
CP12; CYPIA2; P3-450; P450(PA); P450-3; CYPD45; P-450d; RATCYPD45; CP1A2_HUMAN; CYP1A2; Cholesterol 25-hydroxylase; Cytochrome P(3)450; Cytochrome P450 4; Cytochrome P450-P3; Hydroperoxy icosatetraenoate dehydratase; 1.14.14.1; CP1A2_MOUSE; Cytochrome P450-P2; Cyp1a-2; CP1A2_RAT; Cytochrome P-448; Cytochrome P-450d; Cytochrome P450-D;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human Cytochrome P450 1A2: 200-247/516
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
19B9
理论分子量
58
检测分子量
58
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究领域
Cancer > Cancer Metabolism > Cellular metabolic process
Cardiovascular > Lipids / Lipoproteins > Lipid Metabolism > Cytochromes
Metabolism > Pathways and Processes > Metabolic signaling pathways > Drug metabolism
Metabolism > Pathways and Processes > Metabolic signaling pathways > Lipid and lipoprotein metabolism > Lipases
Metabolism > Pathways and Processes > Mitochondrial Metabolism > Cytochromes
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
合成与降解（Synthesis and Degradation）
背景资料
A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase).
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | 1:500-2000 | |
| Flow-Cyt | Human | 1:50-100 | |
| ICC/IF | Human | 1:50-200 |
交叉反应
交叉反应: Human
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靶标
基因名
CYP1A2
蛋白名
Cytochrome P450 1A2
亚细胞定位
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
组织特异性
Liver.
相似性
Belongs to the cytochrome P450 family.
功能
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N3-demethylation. Also acts in the metabolism of aflatoxin B1 and acetaminophen. Participates in the bioactivation of carcinogenic aromatic and heterocyclic amines. Catalizes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin.
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