核因子κB抑制蛋白E重组兔单抗
Rrmab®兔单抗
货号：bsm-61720R
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概述
产品编号
bsm-61720R
产品类型
重组兔单抗
英文名称
IKK epsilon Recombinant Rabbit mAb
中文名称
核因子κB抑制蛋白E重组兔单抗
英文别名
IKK-E; IKK-i; IKKE; IKKI; IKKE_HUMAN; IKBKE; I-kappa-B kinase epsilon; IKK-epsilon; Inducible I kappa-B kinase (IKK-i); 2.7.11.10; KIAA0151;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human IKK epsilon: 32-65
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
5D10
理论分子量
80
检测分子量
80
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究领域
Cancer > Oncoproteins/suppressors > Oncoproteins > Signal transducers
Cancer > Signal transduction > Protein phosphorylation > Serine/threonine kinases
Epigenetics and Nuclear Signaling > Cell cycle > Kinases/Phosphatases
Immunology > Innate Immunity > TLR Signaling
Signal Transduction > Protein Phosphorylation > Ser / Thr Kinases > Other Kinases
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍
I kappa B kinase epsilon(IKKe)也是丝氨酸/苏氨酸蛋白激酶家族.可以磷酸化IkB，从而激活NF-kB通路，促进NF-kB核移位,并最终降解NF-kB的抑制剂. IKKe可表达在很多组织细胞中;胸腺、胰腺、脾、胎盘、外周血白细胞，也可少量表达在肺、肾、前列腺癌、卵巢、结肠。但最多表达在乳腺肿瘤上，IKBKE在人类乳腺癌中明显高表达，这种新的乳腺癌易感基因在肿瘤的形成和发展中起着及其关键的作用。IKBKE蛋白不同于乳腺癌易感基因BRCA1和BRCA2，是先天具有的。带有这些遗传变异的这些基因的女性会增加早发乳腺癌的风险。
背景资料
Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. May play a special role in the immune response. Protects cells against DNA damage-induced cell death.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | 1:500-2000 | |
| IHC-P | Human | 1:100-500 | |
| IHC-F | Human | 1:100-500 | |
| IF | Human | 1:100-500 |
交叉反应
交叉反应: Human
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靶标
基因名
IKBKE
蛋白名
Inhibitor of nuclear factor kappa-B kinase subunit epsilon
亚基
May interact with MAVS/IPS1. Interacts with AZI2. Interacts with SIKE1. Interacts with TICAM1/TRIF, IRF3 and DDX58/RIG-I, interactions are disrupted by the interaction between IKBKE and SIKE1. Interacts with TOPORS; induced by DNA damage. Interacts with CYLD.
亚细胞定位
Cytoplasm. Nucleus. Nucleus, PML body.
组织特异性
Highly expressed in spleen followed by thymus, peripheral blood leukocytes, pancreas, placenta. Weakly expressed in lung, kidney, prostate, ovary and colon.
翻译后修饰
Autophosphorylated and phosphorylated by IKBKB/IKKB.
Sumoylation by TOPORS upon DNA damage is required for protection of cells against DNA damage-induced cell death. Desumoylated by SENP1.
Sumoylation by TOPORS upon DNA damage is required for protection of cells against DNA damage-induced cell death. Desumoylated by SENP1.
相似性
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.
Contains 1 protein kinase domain.
Contains 1 protein kinase domain.
功能
Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. May play a special role in the immune response. Protects cells against DNA damage-induced cell death.
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