IKK epsilon Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF | Bioss

bsm-61720R

重组兔单抗

IKK epsilon Recombinant Rabbit mAb

核因子κB抑制蛋白E重组兔单抗

IKK-E; IKK-i; IKKE; IKKI; IKKE_HUMAN; IKBKE; I-kappa-B kinase epsilon; IKK-epsilon; Inducible I kappa-B kinase (IKK-i); 2.7.11.10; KIAA0151; inhibitor of nuclear factor kappa B kinase subunit epsilon; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon

Rabbit

A synthesized peptide derived from human IKK epsilon: 32-65

IgG

Liquid

affinity purified by Protein A

Recombinant

5D10

80 kDa

75 kDa

10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

I kappa B kinase epsilon(IKKe)也是丝氨酸/苏氨酸蛋白激酶家族.可以磷酸化IkB，从而激活NF-kB通路，促进NF-kB核移位,并最终降解NF-kB的抑制剂. IKKe可表达在很多组织细胞中;胸腺、胰腺、脾、胎盘、外周血白细胞，也可少量表达在肺、肾、前列腺癌、卵巢、结肠。但最多表达在乳腺肿瘤上，IKBKE在人类乳腺癌中明显高表达，这种新的乳腺癌易感基因在肿瘤的形成和发展中起着及其关键的作用。IKBKE蛋白不同于乳腺癌易感基因BRCA1和BRCA2，是先天具有的。带有这些遗传变异的这些基因的女性会增加早发乳腺癌的风险。

Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. May play a special role in the immune response. Protects cells against DNA damage-induced cell death.

IKBKE

Inhibitor of nuclear factor kappa-B kinase subunit epsilon

May interact with MAVS/IPS1. Interacts with AZI2. Interacts with SIKE1. Interacts with TICAM1/TRIF, IRF3 and DDX58/RIG-I, interactions are disrupted by the interaction between IKBKE and SIKE1. Interacts with TOPORS; induced by DNA damage. Interacts with CYLD.

Cytoplasm. Nucleus. Nucleus, PML body.

Highly expressed in spleen followed by thymus, peripheral blood leukocytes, pancreas, placenta. Weakly expressed in lung, kidney, prostate, ovary and colon.

Autophosphorylated and phosphorylated by IKBKB/IKKB.
Sumoylation by TOPORS upon DNA damage is required for protection of cells against DNA damage-induced cell death. Desumoylated by SENP1.

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.
Contains 1 protein kinase domain.

Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. May play a special role in the immune response. Protects cells against DNA damage-induced cell death.