PDK2 Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF,IP,Flow-Cyt | Bioss

bsm-61695R

重组兔单抗、mIHC精品抗体

PDK2 Recombinant Rabbit mAb

丙酮酸脱氢酶激酶亚型2重组兔单抗

PDHK2; PDKII; PDK2_HUMAN; PDK2; Pyruvate dehydrogenase kinase isoform 2 (PDH kinase 2 | PDKII); 2.7.11.2; PDK2_MOUSE; Pyruvate dehydrogenase kinase isoform 2 (PDH kinase 2); PDK2_RAT; PDK P45; pyruvate dehydrogenase kinase 2; pyruvate dehydrogenase kinase, isoenzyme 2; pyruvate dehydrogenase kinase, isozyme 2

Rabbit

A synthesized peptide derived from human PDK2: 350-407/407

IgG

Liquid

affinity purified by Protein A

Recombinant

8H9

46 kDa

46 kDa

10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Kinase that plays a key role in the regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism. Mediates cellular responses to insulin.

PDK2

[Pyruvate dehydrogenase(acetyl-transferring)] kinase isozyme 2, mitochondrial

Homodimer, and heterodimer with PDK1. Interacts with the pyruvate dehydrogenase complex subunit DLAT, and is part of the multimeric pyruvate dehydrogenase complex that contains multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (DLAT, E2) and lipoamide dehydrogenase (DLD, E3).

Mitochondrion matrix.

Expressed in many tissues, with the highest level in heart and skeletal muscle, intermediate levels in brain, kidney, pancreas and liver, and low levels in placenta and lung.

Belongs to the PDK/BCKDK protein kinase family.
Contains 1 histidine kinase domain.

Serine/threonine kinase that plays a key role in the regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism. Mediates cellular responses to insulin. Plays an important role in maintaining normal blood glucose levels and in metabolic adaptation to nutrient availability. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. Plays a role in the regulation of cell proliferation and in resistance to apoptosis under oxidative stress. Plays a role in p53/TP53-mediated apoptosis.