瞬时受体电位离子通道蛋白7重组兔单抗（M亚家族）
Rrmab®兔单抗
货号：bsm-61679R
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概述
产品编号
bsm-61679R
产品类型
重组兔单抗、离子通道抗体
英文名称
TRPM7 Recombinant Rabbit mAb
中文名称
瞬时受体电位离子通道蛋白7重组兔单抗（M亚家族）
英文别名
ALSPDC; CHAK; CHAK1; LTRPC7; LTrpC-7; TRP-PLIK; 2310022G15Rik; 4833414K03Rik; 5033407O22Rik; Ltpr7; TRPPLIK; TRPM7_HUMAN; TRPM7; Channel-kinase 1; Long transient receptor potential channel 7 (LTrpC-7 | LTrpC7); 2.7.11.1; TRPM7_MOUSE; Transient receptor potential-phospholipase C-interacting kinase (TRP-PLIK); TRPM7_RAT;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human TRPM7: 1800-1865/1865
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
3E3
理论分子量
213
检测分子量
213
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究领域
Neuroscience > Neurology process > Neurodegenerative disease > Amyotrophic lateral sclerosis
Neuroscience > Neurology process > Neurodegenerative disease > Parkinson's disease
Neuroscience > Neurotransmission > Intracellular Signaling > Kinases
Neuroscience > Neurotransmission > Receptors / Channels > More Ion Channels
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium.Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Involved in TNF-induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1).
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| IHC-P | Human, Mouse, Rat | 1:50-200 | |
| IHC-F | Human, Mouse, Rat | 1:50-200 | |
| IF | Human, Mouse, Rat | 1:50-200 | |
| Flow-Cyt | Human, Mouse, Rat | 1:50-100 | |
| ICC/IF | Human, Mouse, Rat | 1:50-200 |
交叉反应
交叉反应: Human, Mouse, Rat
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靶标
基因名
TRPM7
蛋白名
Transient receptor potential cation channel subfamily M member 7
亚基
Homodimer. Interacts with PLCB1. Forms heterodimers with TRPM6.
亚细胞定位
Membrane; Multi-pass membrane protein
翻译后修饰
Autophosphorylated (By similarity).
疾病
Defects in TRPM7 are a cause of susceptibility to amyotrophic lateral sclerosis-parkinsonism/dementia complex type 1 (ALS-PDC1) [MIM:105500]; also called amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam or Guam disease. Amyotrophic lateral sclerosis-parkinsonism/dementia complex type 1 is a neurodegenerative disorder characterized by chronic, progressive and uniformly fatal amyotrophic lateral sclerosis and parkinsonism-dementia. Both diseases are known to occur in the same kindred, the same sibship and even the same individual.
相似性
In the C-terminal section; belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.
In the N-terminal section; belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM7 sub-subfamily.
Contains 1 alpha-type protein kinase domain.
In the N-terminal section; belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM7 sub-subfamily.
Contains 1 alpha-type protein kinase domain.
功能
Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1).
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