Fadd Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF,Flow-Cyt | Bioss

bsm-61661R

重组兔单抗

Fadd Recombinant Rabbit mAb

Fas死亡结构域相关蛋白重组兔单抗

Mort1/FADD; FADD_MOUSE; Fadd; FAS-associating death domain-containing protein; Mediator of receptor induced toxicity; Mort1; GIG3; IMD90; FADD_HUMAN; Growth-inhibiting gene 3 protein; Fas associated via death domain; Fas (TNFRSF6)-associated via death domain; Fas-associating protein with death domain; mediator of receptor-induced toxicity

Rabbit

A synthesized peptide derived from mouse Fadd: 150-205/205

IgG

Liquid

affinity purified by Protein A

Recombinant

6B5

23 kDa

27 kDa

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

FADD属于TNFR家族，有死亡区的Fas相关蛋白。

Apoptotic adapter molecule that recruits caspases CASP8 or CASP10 to the activated FAS/CD95 or TNFRSF1A/TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. Active CASP8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.

FADD

FAS-associated death domain protein

Can self-associate. Interacts with CFLAR, PEA15 and MBD4. When phosphorylated, part of a complex containing HIPK3 and FAS. May interact with MAVS/IPS1. Interacts with MOCV v-CFLAR protein and LRDD. Interacts (via death domain) with FAS (via death domain). Interacts with CASP8.

Expressed in a wide variety of tissues, except for peripheral blood mononuclear leukocytes.

The interaction between the FAS and FADD death domains is crucial for the formation of the death-inducing signaling complex (DISC).
Defects in FADD are the cause of infections recurrent associated with encephalopathy hepatic dysfunction and cardiovascular malformations (IEHDCM) [MIM:613759]. A condition with biological features of autoimmune lymphoproliferative syndrome such as high-circulating CD4(-)CD8(-)TCR-alpha-beta(+) T-cell counts, and elevated IL10 and FASL levels. Affected individuals suffer from recurrent, stereotypical episodes of fever, encephalopathy, and mild liver dysfunction sometimes accompanied by generalized seizures. The episodes can be triggered by varicella zoster virus (VZV), measles mumps rubella (MMR) attenuated vaccine, parainfluenza virus, and Epstein-Barr virus (EBV).

Contains 1 death domain.
Contains 1 DED (death effector) domain.

Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.