TRADD Recombinant Rabbit mAb (一抗) - WB,ICC/IF,IP | Bioss
Rrmab?兔单抗
货号：bsm-61653R
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概述
产品编号
bsm-61653R
产品类型
重组兔单抗
英文名称
TRADD Recombinant Rabbit mAb
中文名称
肿瘤坏死因子受体1相关死亡域蛋白重组兔单抗
英文别名
Hs.89862; 9130005N23Rik; TRADD_HUMAN; TRADD; TNFR1-associated DEATH domain protein; TNFRSF1A-associated via death domain; TRADD_MOUSE;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human TRADD: 210-312
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
2C10
理论分子量
34 kDa
检测分子量
35 kDa
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究领域
Cancer > Cell Death > Apoptosis > Receptors > Death receptors & ligands > TRADD
Cancer > Invasion/microenvironment > Apoptosis > Death receptors & ligands > TRADD
Cardiovascular > Atherosclerosis > Vascular Inflammation > Inflammatory mediators
Cell Biology > Apoptosis > Extracellular Signals > Death Ligands
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
TRADD在凋亡信号传导中起重要作用，近年来多用于研究其在肿瘤中的作用，探讨TRADD在促细胞凋亡和促细胞存活的机制如何控制，将有利于我们了解肿瘤发病机理。
背景资料
Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD.Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | Mouse, Rat | 1:500-2000 |
| ICC/IF | Human, Mouse, Rat | 1:50-200 | |
| IP | Human, Mouse, Rat | 1:20-50 |
交叉反应
交叉反应: Human (predicted: Mouse, Rat)
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靶标
基因名
TRADD
蛋白名
Tumor necrosis factor receptor type 1-associated DEATH domain protein
亚基
Interacts with TRIP12. Heterodimer with TNFRSF1A/TNFR1. Interacts with DAB2IP, FADD, HIPK2, KRT14, KRT16, KRT17, KRT18, RIPK1, SQSTM1, TRAF1, TRAF2 and TRPC4AP.
亚细胞定位
Cytoplasm > cytoskeleton.
组织特异性
Found in all examined tissues.
相似性
Contains 1 death domain.
功能
Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B.
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