TRPM8 Recombinant Rabbit mAb (一抗) - WB | Bioss

bsm-61651R

重组兔单抗、离子通道抗体

TRPM8 Recombinant Rabbit mAb

“冷”蛋白TRPM8重组兔单抗

LTRPC6; LTrpC-6; TRPP8; trp-p8; CMR1; TRPM8_HUMAN; TRPM8; Long transient receptor potential channel 6 (LTrpC-6 | LTrpC6); Transient receptor potential p8 (Trp-p8); TRPM8_MOUSE; TRPM8_RAT; Cold menthol receptor 1; transient receptor potential cation channel subfamily M member 8; transient receptor potential cation channel, subfamily M, member 8

Rabbit

A synthesized peptide derived from human TRPM8: 900-1000

IgG

Liquid

affinity purified by Protein A

Recombinant

4G6

128 kDa

105 kDa

10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

TRPM8与感应热和辣的蛋白质属于同一家族，它存在于特定神经细胞的细胞膜上，成为响应外界信号的开关通道。科学家研究发现，当温度低于27摄氏度或者醇存在的条件下，TRPM8通道都会打开，使钙离子等带正电的粒子进入细胞。 TRPM8的蛋白质在产生冷知觉的过程中起着主导作用，并且控制着低温对机体疼痛的缓解效果, TRPM8故称是“冷”蛋白。

Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating.

TRPM8

Transient receptor potential cation channel subfamily M member 8

Homotetramer (By similarity).

Membrane; Multi-pass membrane protein (Probable).

Expressed in prostate. Also expressed in most in prostate tumors. Also expressed in non-prostatic primary tumors such as colon, lung, breast and skin tumors.

Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM8 ub-subfamily.

Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing.