组蛋白乙酰转移酶KAT7重组兔单抗
Rrmab®兔单抗
货号：bsm-61637R
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概述
产品编号
bsm-61637R
产品类型
重组兔单抗
英文名称
KAT7 Recombinant Rabbit mAb
中文名称
组蛋白乙酰转移酶KAT7重组兔单抗
英文别名
HBO1; HBOA; MYST2; ZC2HC7; KAT7_HUMAN; KAT7; Histone acetyltransferase binding to ORC1; Lysine acetyltransferase 7; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2 (MYST-2); 2.3.1.48; KAT7_MOUSE; KAT7_RAT;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human KAT7: 1-230/611
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
4F8
理论分子量
71
检测分子量
75
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究领域
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
Catalytic subunit of histone acetyltransferase HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), thereby regulating various processes, such as gene transcription, protein ubiquitination, immune regulation, stem cell pluripotent and self-renewal maintenance and embryonic development.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human, Mouse | Rat | 1:500-2000 |
| ICC/IF | Human, Mouse, Rat | 1:50-200 | |
| IP | Human, Mouse, Rat | 1:20-50 |
交叉反应
交叉反应: Human, Mouse (predicted: Rat)
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靶标
基因名
KAT7
蛋白名
Histone acetyltransferase KAT6B
亚细胞定位
Nucleus; nucleoplasm.
组织特异性
Ubiquitously expressed, with highest levels in testis.
翻译后修饰
Phosphorylated upon DNA damage, probably by ATM or ATR.
相似性
Belongs to the MYST (SAS/MOZ) family.
Contains 1 C2HC-type zinc finger.
Contains 1 C2HC-type zinc finger.
功能
Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Specifically represses AR-mediated transcription.
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