ULK3重组兔单抗
Rrmab®兔单抗
货号：bsm-61618R
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概述
产品编号
bsm-61618R
产品类型
重组兔单抗
英文名称
ULK3 Recombinant Rabbit mAb
中文名称
ULK3重组兔单抗
英文别名
ULK3_HUMAN; ULK3; Unc-51-like kinase 3; 2.7.11.1;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human ULK3: 400-470/470
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
5E10
理论分子量
53
检测分子量
53
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
背景资料
Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | 1:500-2000 | |
| IHC-P | Human | 1:50-200 | |
| IHC-F | Human | 1:50-200 | |
| IF | Human | 1:50-200 | |
| Flow-Cyt | Human | 1:50-100 | |
| ICC/IF | Human | 1:50-200 |
交叉反应
交叉反应: Human
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靶标
基因名
ULK3
蛋白名
unc-51 like kinase 3
亚细胞定位
Cytoplasm.
组织特异性
Widely expressed. Highest levels observed in fetal brain. In adult tissues, high levels in brain, liver and kidney, moderate levels in testis and adrenal gland and low levels in heart, lung, stomach, thymus, prostate and placenta. In the brain, highest expression in the hippocampus, high levels also detected in the cerebellum, olfactory bulb and optice nerve. In the central nervous system, lowest levels in the spinal cord.
翻译后修饰
Autophosphorylated in vitro.
相似性
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
Contains 2 MIT domains.
Contains 1 protein kinase domain.
Contains 2 MIT domains.
Contains 1 protein kinase domain.
功能
Serine/threonine protein kinase which enhances GLI1 and GLI2 transcriptional activity and consequently positively regulates GLI-dependent SHH signaling. May exert this function by promoting GLI1 nuclear localization. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently.
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