ATG4A | Autophagin-2 Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF,Flow-Cyt,ICC/IF,IP | Bioss

bsm-61617R

重组兔单抗

ATG4A | Autophagin-2 Recombinant Rabbit mAb

自噬相关蛋白4A重组兔单抗

APG4A; AUTL2; HsAPG4A; Atg4al; ATG4A_HUMAN; ATG4A; AUT-like 2 cysteine endopeptidase; Autophagy-related cysteine endopeptidase 2 (Autophagin-2); Autophagy-related protein 4 homolog A (HsAPG4A | hAPG4A); 3.4.22.-; ATG4A_MOUSE; Autophagy-related protein 4 homolog A; autophagy related 4A cysteine peptidase; AUT-like 2, cysteine endopeptidase (S. cerevisiae); APG4 autophagy 4 homolog A (S. cerevisiae); ATG4 autophagy related 4 homolog A (S. cerevisiae); autophagy related 4A, cysteine peptidase

Rabbit

A synthesized peptide derived from human Cysteine protease ATG4A: 1-84

IgG

Liquid

affinity purified by Protein A

Recombinant

6D4

45 kDa

45 kDa

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.The protease activity is required for proteolytic activation of ATG8 family proteins: cleaves the C-terminal amino acid of ATG8 proteins to reveal a C-terminal glycine.

ATG4A

Cysteine protease ATG4A

Cytoplasm (Probable).

Widely expressed, at a low level, and the highest expression is observed in skeletal muscle and brain. Also detected in fetal liver.

Belongs to the peptidase C54 family.

Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes. Preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP.