Heterodimer with SLC3A2, that functions as an antiporter by mediating the exchange of extracellular anionic L-cystine and intracellular L-glutamate across the cellular plasma membrane.Provides L-cystine for the maintenance of the redox balance between extracellular L-cystine and L-cysteine and for the maintenance of the intracellular levels of glutathione that is essential for cells protection from oxidative stress.
产品应用
应用
已检合格种属
预测种属
推荐稀释比例
WB
Human, Mouse, Rat
1:500-2000
ICC/IF
Human, Mouse, Rat
1:50-200
IP
Human, Mouse, Rat
1:20-50
交叉反应
交叉反应: Human, Mouse, Rat
相关产品
暂无相关产品
靶标
基因名
SLC7A11
蛋白名
Cystine/glutamate transporter
亚基
Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc (By similarity).
亚细胞定位
Membrane; Multi-pass membrane protein.
相似性
Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
功能
Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate.