驱动蛋白样蛋白1/甲状腺激素受体相互作用蛋白5重组兔单抗
Rrmab®兔单抗
货号：bsm-61607R
产品详情
相关标记
相关产品
相关文献
常见问题
概述
产品编号
bsm-61607R
产品类型
重组兔单抗
英文名称
KIF11 Recombinant Rabbit mAb
中文名称
驱动蛋白样蛋白1/甲状腺激素受体相互作用蛋白5重组兔单抗
英文别名
EG5; HKSP; KNSL1; MCLMR; TRIP5; KIF11_HUMAN; KIF11; Kinesin-like protein 1; Kinesin-like spindle protein HKSP; Kinesin-related motor protein Eg5; Thyroid receptor-interacting protein 5 (TR-interacting protein 5 | TRIP-5);
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human KIF11: 850-1056/1056
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
11C8
理论分子量
119
检测分子量
119
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究领域
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
背景资料
Motor protein required for establishing a bipolar spindle. Blocking of KIF11 prevents centrosome migration and arrest cells in mitosis with monoastral microtubule arrays.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | 1:500-2000 | |
| ICC/IF | Human | 1:50-200 | |
| IP | Human | 1:20-50 |
交叉反应
交叉反应: Human
相关产品
暂无相关产品
靶标
基因名
KIF11
蛋白名
Kinesin-like protein KIF11
亚基
Interacts with the thyroid hormone receptor in the presence of thyroid hormone. Component of a large chromatin remodeling complex, at least composed of MYSM1, PCAF, RBM10 and KIF11/TRIP5. Interacts (via C-terminus) with the kinase NEK6 in both interphase and mitosis.
亚细胞定位
Cytoplasm. Cytoplasm, cytoskeleton, spindle pole.
翻译后修饰
Phosphorylated exclusively on serine during S phase, but on both serine and Thr-926 during mitosis, so controlling the association of KIF11 with the spindle apparatus (probably during early prophase). Phosphorylated upon DNA damage, probably by ATM or ATR.
A subset of this protein primarily localized at the spindle pole is phosphorylated by NEK6 during mitosis; phosphorylation is required for mitotic function.
A subset of this protein primarily localized at the spindle pole is phosphorylated by NEK6 during mitosis; phosphorylation is required for mitotic function.
相似性
Belongs to the kinesin-like protein family. BimC subfamily.
Contains 1 kinesin-motor domain.
Contains 1 kinesin-motor domain.
功能
Motor protein required for establishing a bipolar spindle. Blocking of KIF11 prevents centrosome migration and arrest cells in mitosis with monoastral microtubule arrays.
标记抗体
暂无标记数据
同靶标产品
暂无同靶标产品
相关文献
提示: 发表研究结果有使用 bsm-61607R 时请让我们知道，以便我们可以引用参考文章。作为回馈，资料提供者将获得我们送上的小礼品。
暂无相关文献
常见问题
暂无常见问题