KIF11 Recombinant Rabbit mAb (一抗) - WB,ICC/IF,IP | Bioss

bsm-61607R

重组兔单抗

KIF11 Recombinant Rabbit mAb

驱动蛋白样蛋白1/甲状腺激素受体相互作用蛋白5重组兔单抗

EG5; HKSP; KNSL1; MCLMR; TRIP5; KIF11_HUMAN; KIF11; Kinesin-like protein 1; Kinesin-like spindle protein HKSP; Kinesin-related motor protein Eg5; Thyroid receptor-interacting protein 5 (TR-interacting protein 5 | TRIP-5); kinesin family member 11; kinesin-like 1

Rabbit

A synthesized peptide derived from human KIF11: 850-1056/1056

IgG

Liquid

affinity purified by Protein A

Recombinant

11C8

119 kDa

120 kDa

10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Motor protein required for establishing a bipolar spindle. Blocking of KIF11 prevents centrosome migration and arrest cells in mitosis with monoastral microtubule arrays.

KIF11

Kinesin-like protein KIF11

Interacts with the thyroid hormone receptor in the presence of thyroid hormone. Component of a large chromatin remodeling complex, at least composed of MYSM1, PCAF, RBM10 and KIF11/TRIP5. Interacts (via C-terminus) with the kinase NEK6 in both interphase and mitosis.

Cytoplasm. Cytoplasm, cytoskeleton, spindle pole.

Phosphorylated exclusively on serine during S phase, but on both serine and Thr-926 during mitosis, so controlling the association of KIF11 with the spindle apparatus (probably during early prophase). Phosphorylated upon DNA damage, probably by ATM or ATR.
A subset of this protein primarily localized at the spindle pole is phosphorylated by NEK6 during mitosis; phosphorylation is required for mitotic function.

Belongs to the kinesin-like protein family. BimC subfamily.
Contains 1 kinesin-motor domain.

Motor protein required for establishing a bipolar spindle. Blocking of KIF11 prevents centrosome migration and arrest cells in mitosis with monoastral microtubule arrays.