溶血磷脂酸受体蛋白1/EDG2重组兔单抗

Rrmab®兔单抗
2026-01-04~2026-02-28,RR26012026-01-04~2026-02-28,TR
溶血磷脂酸受体蛋白1/EDG2重组兔单抗
货号:bsm-61606R
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概述

产品编号
bsm-61606R
产品类型
重组兔单抗
英文名称
LPA1 Recombinant Rabbit mAb
中文名称
溶血磷脂酸受体蛋白1/EDG2重组兔单抗
英文别名
EDG2; Gpcr26; LPA1; Mrec1.3; VZG1; edg-2; rec.1.3; vzg-1; Kdt2; LPAR1_BOVIN; LPAR1; LPA receptor 1; LPA-1; Lysophosphatidic acid receptor Edg-2; Rec1.3; LPAR1_HUMAN; LPAR1_MOUSE; LPAR1_RAT; Gpcr91; LPAR1_SHEEP;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human LPA receptor 1: 15-60
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
7C2
理论分子量
41
检测分子量
39
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
背景资料
Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G12/G13, and G(q) families of heteromeric G proteins. Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels.
溶血磷脂酸受体蛋白1/EDG2重组兔单抗溶血磷脂酸受体蛋白1/EDG2重组兔单抗溶血磷脂酸受体蛋白1/EDG2重组兔单抗

产品应用

应用已检合格种属预测种属推荐稀释比例
IHC-PHuman1:100-500
IHC-FHuman1:100-500
IFHuman1:100-500

交叉反应

交叉反应: Human

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靶标

基因名
LPAR1
蛋白名
Lysophosphatidic acid receptor 1
亚基
Interacts with RALA and ADRBK1.
亚细胞定位
Cell surface. Cell membrane; Multi-pass membrane protein. Note=Prior to LPA treatment found predominantly at the cell surface but in the presence of LPA co-localizes with RALA in the endocytic vesicles.
组织特异性
Expressed in many adult organs, including brain, heart, colon, small intestine, placenta, prostate, ovary, pancreas, testes, spleen, skeletal muscle, and kidney. Little or no expression in liver, lung, thymus, or peripheral blood leukocytes.
相似性
Belongs to the G-protein coupled receptor 1 family.
功能
Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Stimulates phospholipase C (PLC) activity in a manner that is dependent on RALA activation.

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