甲状旁腺激素重组兔单抗

PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells.

产品应用

应用	已检合格种属	预测种属	推荐稀释比例
WB	Human		1:1000-2000
IHC-P		Human	1:100-200
IHC-F		Human	1:100-200
IF		Human	1:100-200

交叉反应

交叉反应: Human

靶标

基因名

PTH

蛋白名

Parathyroid hormone

亚基

Interacts with PTH1R (via N-terminal extracellular domain).

亚细胞定位

Secreted.

疾病

Defects in PTH are a cause of familial isolated hypoparathyroidism (FIH) [MIM:146200]; also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.

相似性

Belongs to the parathyroid hormone family.

功能

PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells.

标记抗体

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同靶标产品

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常见问题

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