CD55 Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF | Bioss
Rrmab?兔单抗
货号：bsm-61587R
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概述
产品编号
bsm-61587R
产品类型
重组兔单抗
英文名称
CD55 Recombinant Rabbit mAb
中文名称
衰变加速因子CD55重组兔单抗
英文别名
CHAPLE; CR; CROM; DAF; TC; DAF_HUMAN; CD55;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human CD55: 100-150/381
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
3A5
理论分子量
41 kDa
检测分子量
70-75 kDa
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究领域
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍
衰变加速因子（CD55）是血细胞膜上糖化磷脂酰肌醇（GPI）锚定蛋白，具有抑制补体系统激活，参与信号传递，有协助T淋巴细胞活化功能。
背景资料
This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | 1:500-2000 | |
| IHC-P | Human | 1:50-200 | |
| IHC-F | Human | 1:50-200 | |
| IF | Human | 1:50-200 |
交叉反应
交叉反应: Human
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靶标
基因名
CD55
蛋白名
Complement decay-accelerating factor
亚基
Monomer (major form) and non-disulfide-linked, covalent homodimer (minor form). Binds to coxsackievirus A21, coxsackieviruses B1, B3 and B5, human enterovirus 70, human echoviruses 6, 7, 11, 12, 20 and 21 capsid proteins and acts as a receptor for these viruses.
亚细胞定位
Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Cell membrane; Lipid-anchor, GPI-anchor.
Isoform 2: Cell membrane; Lipid-anchor, GPI-anchor.
组织特异性
Expressed on the plasma membranes of all cell types that are in intimate contact with plasma complement proteins. It is also found on the surfaces of epithelial cells lining extracellular compartments, and variants of the molecule are present in body fluids and in extracellular matrix.
翻译后修饰
The Ser/Thr-rich domain is heavily O-glycosylated.
相似性
Belongs to the receptors of complement activation (RCA) family.
Contains 4 Sushi (CCP/SCR) domains.
Contains 4 Sushi (CCP/SCR) domains.
功能
This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade.
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