IDH2 Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF,Flow-Cyt,ICC/IF | Bioss

bsm-61585R

重组兔单抗

IDH2 Recombinant Rabbit mAb

线粒体异柠檬酸脱氢酶重组兔单抗

D2HGA2; ICD-M; IDH; IDH-2; IDHM; IDP; IDPM; mNADP-IDH; E430004F23; IDHP_HUMAN; IDH2; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase; 1.1.1.42; IDHP_MOUSE; IDHP_RAT; isocitrate dehydrogenase (NADP(+)) 2; isocitrate dehydrogenase 2 (NADP+), mitochondrial; isocitrate dehydrogenase (NADP(+)) 2, mitochondrial

Rabbit

A synthesized peptide derived from human IDH2: 400-452

IgG

Liquid

affinity purified by Protein A

Recombinant

2A6

51 kDa

45 kDa

10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

IDH2

Isocitrate dehydrogenase [NADP], mitochondrial

Homodimer.

Cytoplasm. Peroxisome.

Defects in IDH1 are involved in the development of glioma (GLM) [MIM:137800]. Gliomas are central nervous system neoplasms derived from glial cells and comprise astrocytomas, glioblastoma multiforme, oligodendrogliomas, and ependymomas. Note=Mutations affecting Arg-132 are tissue-specific, and suggest that this residue plays a unique role in the development of high-grade gliomas. Mutations of Arg-132 to Cys, His, Leu or Ser abolish magnesium binding and abolish the conversion of isocitrate to alpha-ketoglutarate. Instead, alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate. Elevated levels of R(-)-2-hydroxyglutarate are correlated with an elevated risk of malignant brain tumors.

Belongs to the isocitrate and isopropylmalate dehydrogenases family.

Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex.