Folate Receptor alpha Recombinant Rabbit mAb (一抗) - WB | Bioss

bsm-61571R

重组兔单抗

Folate Receptor alpha Recombinant Rabbit mAb

叶酸受体α/α-FR 重组兔单抗

FBP; FOLR; FRalpha; NCFTD; FOLR1_HUMAN; FOLR1; FR-alpha; Adult folate-binding protein (FBP); Folate receptor 1; Folate receptor, adult; KB cells FBP; Ovarian tumor-associated antigen MOv18; folate receptor alpha; folate receptor 1 (adult)

Rabbit

A synthesized peptide derived from human FOLR1: 1-60/257

IgG

Liquid

affinity purified by Protein A

Recombinant

4E2

30 kDa

38-42 kDa

10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells.

FOLR1

Folate receptor alpha

Cell membrane. Secreted.

Exclusively expressed in tissues of epithelial origin. Expression is increased in malignant tissues. Expressed in kidney, lung and cerebellum.

Eight disulfide bonds are present.
The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease.

Defects in FOLR1 are the cause of neurodegeneration due to cerebral folate transport deficiency (NCFTD) [MIM:613068]. NCFTD is an autosomal recessive disorder resulting from brain-specific folate deficiency early in life. Onset is apparent in late infancy with severe developmental regression, movement disturbances, epilepsy, and leukodystrophy. Note=Recognition and diagnosis of this disorder is critical because folinic acid therapy can reverse the clinical symptoms and improve brain abnormalities and function.

Belongs to the folate receptor family.

Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells.