叶酸受体α/α-FR 重组兔单抗
Rrmab®兔单抗
货号：bsm-61571R
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概述
产品编号
bsm-61571R
产品类型
重组兔单抗
英文名称
Folate Receptor alpha Recombinant Rabbit mAb
中文名称
叶酸受体α/α-FR 重组兔单抗
英文别名
FBP; FOLR; FRalpha; NCFTD; FOLR1_HUMAN; FOLR1; FR-alpha; Adult folate-binding protein (FBP); Folate receptor 1; Folate receptor, adult; KB cells FBP; Ovarian tumor-associated antigen MOv18;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human FOLR1: 1-60/257
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
4E2
理论分子量
30
检测分子量
37
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
背景资料
Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human, Mouse, Rat | 1:500-2000 |
交叉反应
交叉反应: Human, Mouse, Rat
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靶标
基因名
FOLR1
蛋白名
Folate receptor alpha
亚细胞定位
Cell membrane. Secreted.
组织特异性
Exclusively expressed in tissues of epithelial origin. Expression is increased in malignant tissues. Expressed in kidney, lung and cerebellum.
翻译后修饰
Eight disulfide bonds are present.
The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease.
The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease.
疾病
Defects in FOLR1 are the cause of neurodegeneration due to cerebral folate transport deficiency (NCFTD) [MIM:613068]. NCFTD is an autosomal recessive disorder resulting from brain-specific folate deficiency early in life. Onset is apparent in late infancy with severe developmental regression, movement disturbances, epilepsy, and leukodystrophy. Note=Recognition and diagnosis of this disorder is critical because folinic acid therapy can reverse the clinical symptoms and improve brain abnormalities and function.
相似性
Belongs to the folate receptor family.
功能
Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells.
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