细胞色素P450 3A4重组兔单抗
Rrmab®兔单抗
货号：bsm-61566R
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概述
产品编号
bsm-61566R
产品类型
重组兔单抗、mIHC精品抗体
英文名称
CYP3A4 Recombinant Rabbit mAb
中文名称
细胞色素P450 3A4重组兔单抗
英文别名
CP33; CP34; CYP3A; CYP3A3; CYPIIIA3; CYPIIIA4; HLP; NF-25; P450C3; P450PCN1; VDDR3; CP3A4_HUMAN; CYP3A4; 1,4-cineole 2-exo-monooxygenase; 1,8-cineole 2-exo-monooxygenase; Albendazole monooxygenase (sulfoxide-forming); Albendazole sulfoxidase; Cholesterol 25-hydroxylase; Cytochrome P450 3A3; Cytochrome P450 HLp; Cytochrome P450 NF-25; Cytochrome P450-PCN1; Nifedipine oxidase; Quinine 3-monooxygenase; 1.14.14.1;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human Cytochrome P450 3A4: 450-503/503
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
1F9
理论分子量
57
检测分子量
57
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究领域
Cardiovascular > Lipids / Lipoproteins > Lipid Metabolism > Cytochromes
Metabolism > Pathways and Processes > Metabolic signaling pathways > Drug metabolism
Metabolism > Pathways and Processes > Metabolic signaling pathways > Lipid and lipoprotein metabolism > Lipases
Metabolism > Pathways and Processes > Mitochondrial Metabolism > Cytochromes
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍
细胞色素3A4(CYP3A4)是细胞色素P450 超家族成员之一, 主要存在于肝脏中和小肠中。它是人类药物代谢酶中的最重要的酶, CYP3A4与外源性致癌物、抗癌药物和内源性类固醇激素、维生素、脂肪酸的代谢转化密切相关。
背景资料
A cytochrome P450 monooxygenase involved in the metabolism of sterols, steroid hormones, retinoids and fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | 1:500-2000 | |
| IHC-P | Human | 1:100-500 | |
| IHC-F | Human | 1:100-500 | |
| IF | Human | 1:100-500 | |
| IP | Human | 1:20-50 |
交叉反应
交叉反应: Human
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靶标
基因名
CYP3A4
蛋白名
Cytochrome P450 3A4
亚细胞定位
Endoplasmic reticulum, membrane bound.
组织特异性
Expressed in prostate and liver. According to some authors, it is not expressed in brain (PubMed:19094056). According to others, weak levels of expression are measured in some brain locations (PubMed:19359404 and PubMed:18545703). Also expressed in epithelium of the small intestine and large intestine, bile duct, nasal mucosa, kidney, adrenal cortex, epithelium of the gastric mucosa with intestinal metaplasia, gallbladder, intercalated ducts of the pancreas, chief cells of the parathyroid and the corpus luteum of the ovary (at protein level).
翻译后修饰
Polyubiquitinated in the presence of AMFR and UBE2G1 and alsoSTUB1/CHIP and UBE2D1 (in vitro).
相似性
Belongs to the cytochrome P450 family.
功能
In animals, P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs. The four major families involved in drug metabolism are CYP 1,2,3, and 4. Cytochrome P450 3A4 [human-3A1 Rat] is abundantly expressed in liver and small intestine and is inducible by barbiturates, glucocorticoids and rifampicin.
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